Distributional behavior of diffusion coefficients obtained by single trajectories in annealed transit time model
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Publication:3302485
Abstract: Local diffusion coefficients in disordered systems such as spin glass systems and living cells are highly heterogeneous and may change over time. Such a time-dependent and spatially heterogeneous environment results in irreproducibility of single-particle-tracking measurements. Irreproducibility of time-averaged observables has been theoretically studied in the context of weak ergodicity breaking in stochastic processes. Here, we provide rigorous descriptions of equilibrium and non-equilibrium diffusion processes for the annealed transit time model, which is a heterogeneous diffusion model in living cells. We give analytical solutions for the mean square displacement (MSD) and the relative standard deviation of the time-averaged MSD for equilibrium and non-equilibrium situations. We find that the time-averaged MSD grows linearly with time and that the diffusion coefficients are intrinsically random in non-equilibrium situations. Our findings pave the way for a theoretical understanding of distributional behavior of the diffusion coefficients in disordered systems.
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Cited in
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