Interplay of curvature-induced micro- and nanodomain structures in multicomponent lipid bilayers

DOI10.1007/S12572-015-0152-ZMaRDI QIDQ336086zbMATH OpenOpenAlexFDO

Authors Leonie Brodbek, Friederike Schmid

Publication date 10 November 2016

Published in International Journal of Advances in Engineering Sciences and Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1510.05171

zbMATH Keywords

elasticityGinzburg-Landau theorycurvaturelipid bilayerslipid raftsmulticomponent membranes

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37) Membranes (74K15)

Abstract: We discuss different mechanisms for curvature-induced domain formation in multicomponent lipid membranes and present a theoretical model that allows us to study the interplay between the domains. The model represents the membrane by two coupled monolayers, which each carry an additional order parameter field describing the local lipid composition. The spontaneous curvature of each monolayer is coupled to the local composition, moreover, the lipid compositions on opposing monolayers are coupled to each other. Using this model, we calculate the phase behavior of the bilayer in mean-field approximation. The resulting phase diagrams are surprisingly complex and reveal a variety of phases and phase transitions, including a decorated microdomain phase where nanodomains are aligned along the microdomain boundaries. Our results suggest that external membrane tension can be used to control the lateral organization of nanodomains (which might be associated with lipid "rafts") in a multicomponent lipid bilayer.

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Cites work

• scientific article; zbMATH DE number 1966275 (Why is no real title available?)
• Gaussian Cramer-Rao bound for direction estimation of noncircular signals in unknown noise fields

Cited in

(7)

• Interactions in mixed lipid bilayers
• Geodesic curvature driven surface microdomain formation
• Bending models of lipid bilayer membranes: spontaneous curvature and area-difference elasticity
• Curvature-induced spatial ordering of composition in lipid membranes
• Domain formation in membranes near the onset of instability
• Curvature-induced accumulation of anisotropic membrane components and raft formation in cylindrical membrane protrusions
• Local changes in lipid composition to match membrane curvature

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