CLASSIFICATION OF CHEMICAL COMPOUNDS BASED ON THE CORRELATION BETWEEN IN VITRO GENE EXPRESSION PROFILES

DOI10.5109/4476055MaRDI QIDQ3383274zbMATH OpenOpenAlexFDO

Authors Jun-ichi Sato, Akinobu Toyoda, Hidenori Tani, Yasunori Endo, Sadaaki Miyamoto

Publication date 23 September 2021

Published in Bulletin of informatics and cybernetics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2101.01837

zbMATH Keywords

multiobjective combinatorial optimizationstatistical classificationalternatives to animal experimentschemical toxicityin vitro gene expression

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40)

Abstract: Toxicity evaluation of chemical compounds has traditionally relied on animal experiments;however, the demand for non-animal-based prediction methods for toxicology of compounds is increasing worldwide. Our aim was to provide a classification method for compounds based on extit{in vitro} gene expression profiles. The extit{in vitro} gene expression data analyzed in the present study was obtained from our previous study. The data concerned nine compounds typically employed in chemical management.We used agglomerative hierarchical clustering to classify the compounds;however, there was a statistical difficulty to be overcome.We needed to properly extract RNAs for clustering from more than 30,000 RNAs. In order to overcome this difficulty, we introduced a combinatorial optimization problem with respect to both gene expression levels and the correlation between gene expression profiles. Then, the simulated annealing algorithm was used to obtain a good solution for the problem. As a result, the nine compounds were divided into two groups using 1,000 extracted RNAs. Our proposed methodology enables read-across, one of the frameworks for predicting toxicology, based on extit{in vitro} gene expression profiles.

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