On the relationship between sloppiness and identifiability

DOI10.1016/J.MBS.2016.10.009MaRDI QIDQ343083zbMATH OpenOpenAlexWikidataFDO

Authors Oana-Teodora Chis, Julio R. Banga, Eva Balsa-Canto, Alejandro F. Villaverde

Publication date 21 November 2016

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL http://hdl.handle.net/10261/139453

zbMATH Keywords

parameter estimationidentifiabilityoptimal experimental designsloppiness

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

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Cites work

• A survey of model reduction methods for large-scale systems.
• Complexity reduction preserving dynamical behavior of biochemical networks
• Identifiability of large nonlinear biochemical networks
• Identification of parametric models from experimental data. Transl. from an upd. French version by the authors, with the help of John Norton
• Numerical parameter identifiability and estimability: Integrating identifiability, estimability, and optimal sampling design
• On identifiability of nonlinear ODE models and applications in viral dynamics
• Parameter uncertainty in biochemical models described by ordinary differential equations
• Principal component analysis in linear systems: Controllability, observability, and model reduction
• System identifiability based on the power series expansion of the solution

Cited in

(11)

• Optimal experimental design for linear time invariant state-space models
• Observability and structural identifiability of nonlinear biological systems
• Hierarchically goal-oriented prediction of skeletal muscle tissue constitutive behavior considering histological characteristics
• Global sensitivity analysis for the design of nonlinear identification experiments
• Frequency domain identifiability and sloppiness of descriptor systems with an LFT structure
• Parameter redundancy and identifiability in hidden Markov models
• On near-redundancy and identifiability of parametric hazard regression models under censoring
• A computational approach to the structural analysis of uncertain kinetic systems
• Practical identifiability of parametrised models: a review of benefits and limitations of various approaches
• Making predictions using poorly identified mathematical models
• The geometry of sloppiness

Describes a project that uses

Uses Software

• GenSSI
• AMIGO

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