On the relationship between sloppiness and identifiability

DOI10.1016/J.MBS.2016.10.009zbMATH Open1352.92059OpenAlexW2538433428WikidataQ39241976 ScholiaQ39241976MaRDI QIDQ343083FDOQ343083

Authors: Oana-Teodora Chis, Julio R. Banga, Eva Balsa-Canto, Alejandro F. Villaverde 

Publication date: 21 November 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: http://hdl.handle.net/10261/139453

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zbMATH Keywords

parameter estimationidentifiabilityoptimal experimental designsloppiness

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites Work

• On identifiability of nonlinear ODE models and applications in viral dynamics
• Principal component analysis in linear systems: Controllability, observability, and model reduction
• A survey of model reduction methods for large-scale systems.
• Identification of parametric models from experimental data. Transl. from an upd. French version by the authors, with the help of John Norton
• Numerical parameter identifiability and estimability: Integrating identifiability, estimability, and optimal sampling design
• System identifiability based on the power series expansion of the solution
• Complexity reduction preserving dynamical behavior of biochemical networks
• Parameter uncertainty in biochemical models described by ordinary differential equations
• Identifiability of large nonlinear biochemical networks

Cited In (11)

• Making predictions using poorly identified mathematical models
• The geometry of sloppiness
• On near-redundancy and identifiability of parametric hazard regression models under censoring
• Parameter redundancy and identifiability in hidden Markov models
• A computational approach to the structural analysis of uncertain kinetic systems
• Hierarchically goal-oriented prediction of skeletal muscle tissue constitutive behavior considering histological characteristics
• Practical identifiability of parametrised models: a review of benefits and limitations of various approaches
• Optimal experimental design for linear time invariant state-space models
• Global sensitivity analysis for the design of nonlinear identification experiments
• Observability and structural identifiability of nonlinear biological systems
• Frequency domain identifiability and sloppiness of descriptor systems with an LFT structure

Uses Software

• GenSSI
• AMIGO

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