Prospective survival analysis with a general semiparametric shared frailty model: A pseudo full likelihood approach

DOI10.1093/BIOMET/93.3.735MaRDI QIDQ3434089zbMATH OpenOpenAlexFDO

Authors

Publication date 23 April 2007

Published in Biometrika (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0505387

zbMATH Keywords

EM algorithmSurvival analysisFrailty modelCorrelated failure timesdiabetic retinopathy studyProspective family study

Mathematics Subject Classification ID

Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Strong limit theorems (60F15)

Abstract: In this work we provide a simple estimation procedure for a general frailty model for analysis of prospective correlated failure times. Rigorous large-sample theory for the proposed estimators of both the regression coefficient vector and the dependence parameter is given, including consistent variance estimators. In a simulation study under the widely used gamma frailty model, our proposed approach was found to have essentially the same efficiency as the EM-based estimator considered by other authors, with negligible difference between the standard errors of the two estimators. The proposed approach, however, provides a framework capable of handling general frailty distributions with finite moments and yields an explicit consistent variance estimator.

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Cited in

(22)

• The additive risk model for estimation of effect of haplotype match in BMT studies
• Incorporating Correlation for Multivariate Failure Time Data When Cluster Size Is Large
• Estimation in semiparametric conditional shared frailty models with events before study entry
• The proportional odds cumulative incidence model for competing risks
• Marginalized Frailty-Based Illness-Death Model: Application to the UK-Biobank Survival Data
• A Simple Estimator for a Shared Frailty Regression Model
• Quantile Association Regression Models
• Additive gamma frailty models with applications to competing risks in related individuals
• Goodness‐of‐fit tests in proportional hazards models with random effects
• Generalising frailty assumptions in survival analysis: a geometric approach
• Case-control survival analysis with a general semiparametric shared frailty model: A pseudo full likelihood approach
• Estimating haplotype effects for survival data
• Maximum penalized likelihood estimation in a Gamma-frailty model
• Estimation in the positive stable shared frailty Cox proportional hazards model
• Frailty models for familial risk with application to breast cancer
• Clustered survival data with left-truncation
• Pseudo-full likelihood estimation for prospective survival analysis with a general semiparametric shared frailty model: Asymptotic theory
• A Class of Weighted Estimating Equations for Semiparametric Transformation Models with Missing Covariates
• Marginal hazard regression for correlated failure time data with auxiliary covariates
• Saddle-point p-values and confidence intervals based on log-rank tests when dependent subunits of clustered survival data are randomized by random allocation design
• Fitting mixed-effects models when data are left truncated
• Multivariate failure time analysis when only the time to first failure is observed

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