Rescue of the Quasi‐Steady‐State Approximation in a Model for Oscillations in an Enzymatic Cascade

DOI10.1137/060654359MaRDI QIDQ3435014zbMATH OpenOpenAlexFDO

Authors T. Erneux, Albert Goldbeter

Publication date 3 May 2007

Published in SIAM Journal on Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1137/060654359

zbMATH Keywords

enzyme reactionssingular perturbationquasi-steady-state approximationlimit-cycle oscillations

Mathematics Subject Classification ID

Singular perturbations for ordinary differential equations (34E15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Asymptotic expansions of solutions to ordinary differential equations (34E05)

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Cited in

(9)

• Boundedness and stable oscillations in two-dimensional enzyme reduced systems
• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Effects of quasi-steady-state reduction on biophysical models with oscillations
• Quasi steady state and partial equilibrium approximations: their relation and their validity
• Asymptotic analysis of a target-mediated drug disposition model: algorithmic and traditional approaches
• Applying a Rigorous Quasi-Steady State Approximation Method for Proving the Absence of Oscillations in Models of Genetic Circuits
• On the qualitative behaviour of oscillating biochemical systems: the stochastic approach
• The quasi-steady-state approximations revisited: timescales, small parameters, singularities, and normal forms in enzyme kinetics
• Glycolysis in saccharomyces cerevisiae: algorithmic exploration of robustness and origin of oscillations

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