Identifying optimal biomarker combinations for treatment selection via a robust kernel method

DOI10.1111/BIOM.12204zbMATH Open1393.62068OpenAlexW1920839661WikidataQ42182239 ScholiaQ42182239MaRDI QIDQ3465367FDOQ3465367

Authors: Ying Huang, Youyi Fong 

Publication date: 21 January 2016

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4277554

Recommendations

• Combining biomarkers to optimize patient treatment recommendations
• Development and validation of biomarker classifiers for treatment selection
• Efficient screening of predictive biomarkers for individual treatment selection
• The linear combinations of biomarkers which maximize the partial area under the ROC curves
• Identification of biomarker‐by‐treatment interactions in randomized clinical trials with survival outcomes and high‐dimensional spaces
• Selection and combination of biomarkers using ROC method for disease classification and prediction
• Combining binary and continuous biomarkers by maximizing the area under the receiver operating characteristic curve
• A model free approach to combining biomarkers
• Two simple algorithms on linear combination of multiple biomarkers to maximize partial area under the ROC curve

zbMATH Keywords

robustsupport vector machinekernel methodtreatment selectionrandomized trialbiomarker combination

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Title not available (Why is that?)
• Robust Truncated Hinge Loss Support Vector Machines
• Estimating individualized treatment rules using outcome weighted learning
• Performance guarantees for individualized treatment rules
• A robust method for estimating optimal treatment regimes
• Evaluating Markers for Selecting a Patient's Treatment

Cited In (12)

• Assessing treatment-selection markers using a potential outcomes framework
• Estimation of optimal individualized treatment rules using a covariate-specific treatment effect curve with high-dimensional covariates
• Identifying predictive markers for personalized treatment selection
• Evaluating marker-guided treatment selection strategies
• A Sequential Significance Test for Treatment by Covariate Interactions
• Combining biomarkers to optimize patient treatment recommendations
• Single index methods for evaluation of marker-guided treatment rules based on multivariate marker panels
• Identification of the optimal treatment regimen in the presence of missing covariates
• Identification of biomarker‐by‐treatment interactions in randomized clinical trials with survival outcomes and high‐dimensional spaces
• Measuring and visualizing the stability of biomarker selection techniques
• Modern approaches for evaluating treatment effect heterogeneity from clinical trials and observational data
• Learning-based biomarker-assisted rules for optimized clinical benefit under a risk constraint

This page was built for publication: Identifying optimal biomarker combinations for treatment selection via a robust kernel method

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3465367)