Estimation of treatment effects in matched-pair cluster randomized trials by calibrating covariate imbalance between clusters
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Publication:3465386
Abstract: We address estimation of intervention effects in experimental designs in which (a) interventions are assigned at the cluster level; (b) clusters are selected to form pairs, matched on observed characteristics; and (c) intervention is assigned to one cluster at random within each pair. One goal of policy interest is to estimate the average outcome if all clusters in all pairs are assigned control versus if all clusters in all pairs are assigned to intervention. In such designs, inference that ignores individual level covariates can be imprecise because cluster-level assignment can leave substantial imbalance in the covariate distribution between experimental arms within each pair. However, most existing methods that adjust for covariates have estimands that are not of policy interest. We propose a methodology that explicitly balances the observed covariates among clusters in a pair, and retains the original estimand of interest. We demonstrate our approach through the evaluation of the Guided Care program.
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Cites work
- A broad symmetry criterion for nonparametric validity of parametrically based tests in randomized trials
- A prior for the variance in hierarchical models
- Bayesian inference for causal effects: The role of randomization
- Comment: ``The essential role of pair matching in cluster-randomized experiments, with application to the Mexican Universal Health Insurance evaluation
- The essential role of pair matching in cluster-randomized experiments, with application to the Mexican Universal Health Insurance evaluation
Cited in
(12)- Estimation of the overall treatment effect in the presence of interference in cluster-randomized trials of infectious disease prevention
- Propensity score matching in randomized clinical trials
- On mitigating the analytical limitations of finely stratified experiments
- Clustered treatment assignments and sensitivity to unmeasured biases in observational studies
- Accounting for interactions and complex inter‐subject dependency in estimating treatment effect in cluster‐randomized trials with missing outcomes
- Optimal allocation of subjects in a matched pair cluster-randomized trial with fixed number of heterogeneous clusters
- Testing Biased Randomization Assumptions and Quantifying Imperfect Matching and Residual Confounding in Matched Observational Studies
- Inference in Experiments With Matched Pairs
- Design and analysis of three-arm parallel cluster randomized trials with small numbers of clusters
- Covariate balance in simple, stratified and clustered comparative studies
- The essential role of pair matching in cluster-randomized experiments, with application to the Mexican Universal Health Insurance evaluation
- Rejoinder: Matched pairs and the future of cluster-randomized experiments
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