Testing the mean matrix in high-dimensional transposable data

DOI10.1111/BIOM.12257zbMATH Open1419.62460arXiv1404.7683OpenAlexW1892744769WikidataQ35548021 ScholiaQ35548021MaRDI QIDQ3465741FDOQ3465741

Authors: Anestis Touloumis, Simon Tavaré, John Marioni 

Publication date: 22 January 2016

Published in: Biometrics (Search for Journal in Brave)

Abstract: The structural information in high-dimensional transposable data allows us to write the data recorded for each subject in a matrix such that both the rows and the columns correspond to variables of interest. One important problem is to test the null hypothesis that the mean matrix has a particular structure without ignoring the potential dependence structure among and/or between the row and column variables. To address this, we develop a simple and computationally efficient nonparametric testing procedure to assess the hypothesis that, in each predefined subset of columns (rows), the column (row) mean vector remains constant. In simulation studies, the proposed testing procedure seems to have good performance and unlike traditional approaches, it is powerful without leading to inflated nominal sizes. Finally, we illustrate the use of the proposed methodology via two empirical examples from gene expression microarrays.

Full work available at URL: https://arxiv.org/abs/1404.7683

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zbMATH Keywords

hypothesis testingnonparametric testmean matrixhigh-dimensional transposable data

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Hypothesis testing in multivariate analysis (62H15)

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Cited In (6)

• More powerful tests for sparse high-dimensional covariances matrices
• Hypothesis Testing for the Covariance Matrix in High-Dimensional Transposable Data with Kronecker Product Dependence Structure
• A test of the rigid structure of grouped points in high-dimensional data
• Testing high-dimensional mean vector with applications. A normal reference approach
• Linear hypothesis testing in high-dimensional one-way MANOVA
• A review of 20 years of naive tests of significance for high-dimensional mean vectors and covariance matrices

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