Multiscale Modeling of Follicular Ovulation as a Reachability Problem

DOI10.1137/060664495MaRDI QIDQ3523809zbMATH OpenOpenAlexFDO

Authors Nki Echenim, Michel Sorine, Frédérique Clément

Publication date 5 September 2008

Published in Multiscale Modeling & Simulation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0607030

zbMATH Keywords

method of characteristicsbackwards reachable sets

Mathematics Subject Classification ID

Physiology (general) (92C30) Geometric theory, characteristics, transformations in context of PDEs (35A30) Hyperbolic conservation laws (35L65) General biology and biomathematics (92B05) Cell biology (92C37) Attainable sets, reachability (93B03)

Abstract: During each ovarian cycle, only a definite number of follicles ovulate, while the others undergo a degeneration process called atresia. We have designed a multi-scale mathematical model where ovulation and atresia result from a hormonal controlled selection process. A 2D-conservation law describes the age and maturity structuration of the follicular cell population. In this paper, we focus on the operating mode of the control, through the study of the characteristics of the conservation law. We describe in particular the set of microscopic initial conditions leading to the macroscopic phenomenon of either ovulation or atresia, in the framework of backwards reachable sets theory.

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• Controllability for a highly re-entrant manufacturing system with local and nonlocal velocity
• Averaging of a Stochastic Slow-Fast Model for Population Dynamics: Application to the Development of Ovarian Follicles
• Multiscale population dynamics in reproductive biology: singular perturbation reduction in deterministic and stochastic models
• Cell-kinetics based calibration of a multiscale model of structured cell populations in ovarian follicles
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• Cauchy problem for multiscale conservation laws: application to structured cell populations
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• Discontinuous Galerkin methods for weakly coupled hyperbolic multidomain problems
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• Analysis and control of a scalar conservation law modeling a highly re-entrant manufacturing system
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