Multiscale Modeling of Follicular Ovulation as a Reachability Problem

DOI10.1137/060664495zbMATH Open1149.35388arXivq-bio/0607030OpenAlexW3105941137MaRDI QIDQ3523809FDOQ3523809

Authors: Nki Echenim, Michel Sorine, Frédérique Clément 

Publication date: 5 September 2008

Published in: Multiscale Modeling & Simulation (Search for Journal in Brave)

Abstract: During each ovarian cycle, only a definite number of follicles ovulate, while the others undergo a degeneration process called atresia. We have designed a multi-scale mathematical model where ovulation and atresia result from a hormonal controlled selection process. A 2D-conservation law describes the age and maturity structuration of the follicular cell population. In this paper, we focus on the operating mode of the control, through the study of the characteristics of the conservation law. We describe in particular the set of microscopic initial conditions leading to the macroscopic phenomenon of either ovulation or atresia, in the framework of backwards reachable sets theory.

Full work available at URL: https://arxiv.org/abs/q-bio/0607030

Recommendations

• Multi-scale modeling of the follicle selection process in the ovary
• Multiscale Modeling of Follicular Ovulation as a Mass and Maturity Dynamical System
• How do the ovaries count?
• Optimal control of cell mass and maturity in a model of follicular ovulation
• Numerical simulation of the selection process of the ovarian follicles

zbMATH Keywords

method of characteristicsbackwards reachable sets

Mathematics Subject Classification ID

Physiology (general) (92C30) Geometric theory, characteristics, transformations in context of PDEs (35A30) Hyperbolic conservation laws (35L65) General biology and biomathematics (92B05) Cell biology (92C37) Attainable sets, reachability (93B03)

Cited In (14)

• Multi-scale modeling of the follicle selection process in the ovary
• Multiscale Modeling of Follicular Ovulation as a Mass and Maturity Dynamical System
• Title not available (Why is that?)
• Controllability for a scalar conservation law with nonlocal velocity
• Averaging of a Stochastic Slow-Fast Model for Population Dynamics: Application to the Development of Ovarian Follicles
• Multiscale population dynamics in reproductive biology: singular perturbation reduction in deterministic and stochastic models
• Cell-kinetics based calibration of a multiscale model of structured cell populations in ovarian follicles
• Analysis and control of a scalar conservation law modeling a highly re-entrant manufacturing system
• Controllability for a highly re-entrant manufacturing system with local and nonlocal velocity
• Controllability and stabilization of a conservation law modeling a highly re-entrant manufacturing system
• Discontinuous Galerkin methods for weakly coupled hyperbolic multidomain problems
• Cauchy problem for multiscale conservation laws: application to structured cell populations
• Optimal control of cell mass and maturity in a model of follicular ovulation
• Numerical simulation of the selection process of the ovarian follicles

This page was built for publication: Multiscale Modeling of Follicular Ovulation as a Reachability Problem

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3523809)