A Statistical Framework for Quantile Equivalence Clinical Trials with Application to Pharmacokinetic Studies that Bridge from HIV‐Infected Adults to Children

DOI10.1111/J.1541-0420.2007.00982.XzbMATH Open1152.62086OpenAlexW1975372266WikidataQ80663855 ScholiaQ80663855MaRDI QIDQ3549403FDOQ3549403

Authors: Li-Xia Pei, Michael D. Hughes 

Publication date: 22 December 2008

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.1541-0420.2007.00982.x

Recommendations

• Efficiency of bridging between related dose finding studies
• Dynamic calibration of pharmacokinetic parameters in dose-finding studies
• Sample size requirements for evaluation of bridging evidence
• Design and analysis of bridging studies with prior probabilities on the null and alternative hypotheses
• A Group Sequential Approach to Evaluation of Bridging Studies

zbMATH Keywords

clinical trial designbridging clinical trials

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Parameterization and Bayesian Modeling
• Title not available (Why is that?)

Cited In (1)

• Dynamic calibration of pharmacokinetic parameters in dose-finding studies

Uses Software

• WinBUGS

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