Conditional Probability-Based Significance Tests for Sequential Patterns in Multineuronal Spike Trains

DOI10.1162/NECO.2009.12-08-928MaRDI QIDQ3556791zbMATH OpenOpenAlexWikidataFDO

Authors P. S. Sastry, K. P. Unnikrishnan

Publication date 26 April 2010

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0808.3511

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Neural biology (92C20)

Abstract: In this paper we consider the problem of detecting statistically significant sequential patterns in multi-neuronal spike trains. These patterns are characterized by ordered sequences of spikes from different neurons with specific delays between spikes. We have previously proposed a data mining scheme to efficiently discover such patterns which are frequent in the sense that the count of non-overlapping occurrences of the pattern in the data stream is above a threshold. Here we propose a method to determine the statistical significance of these repeating patterns and to set the thresholds automatically. The novelty of our approach is that we use a compound null hypothesis that includes not only models of independent neurons but also models where neurons have weak dependencies. The strength of interaction among the neurons is represented in terms of certain pair-wise conditional probabilities. We specify our null hypothesis by putting an upper bound on all such conditional probabilities. We construct a probabilistic model that captures the counting process and use this to calculate the mean and variance of the count for any pattern. Using this we derive a test of significance for rejecting such a null hypothesis. This also allows us to rank-order different significant patterns. We illustrate the effectiveness of our approach using spike trains generated from a non-homogeneous Poisson model with embedded dependencies.

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Cites work

• A Rate and History-Preserving Resampling Algorithm for Neural Spike Trains

Cited in

(9)

• Neuronal spike train analysis using Gaussian process models
• A Set Probability Technique for Detecting Relative Time Order Across Multiple Neurons
• Spotting neural spike patterns using an adversary background model
• Probability of Repeating Patterns in Simultaneous Neural Data
• Spatiotemporal conditional inference and hypothesis tests for neural ensemble spiking precision
• Goodness-of-fit tests and nonparametric adaptive estimation for spike train analysis
• Statistical significance of episodes with general partial orders
• Discovering injective episodes with general partial orders
• Multiple tests based on a Gaussian approximation of the unitary events method with delayed coincidence count

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