New cancer stochastic models involving both hereditary and nonhereditary cancer cases: a new approach

DOI10.1155/2013/954912MaRDI QIDQ355965zbMATH OpenOpenAlexWikidataFDO

Authors Wai-Yuan Tan, Hong Zhou

Publication date 25 July 2013

Published in ISRN Biomathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 3.0 Unported

Full work available at URL https://doi.org/10.1155/2013/954912

Mathematics Subject Classification ID

Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Medical epidemiology (92C60)

Review text

Summary: To incorporate biologically observed epidemics into multistage models of carcinogenesis, we have developed new stochastic models for human cancers. We have further incorporated genetic segregation of cancer genes into these models to derive generalized mixture models for cancer incidence. Based on these models we have developed a generalized Bayesian approach to estimate the parameters and to predict cancer incidence via Gibbs sampling procedures. We have applied these models to fit and analyze the SEER data of human eye cancers from NCI/NIH. Our results indicate that the models not only provide a logical avenue to incorporate biological information but also fit the data much better than other models. These models would not only provide more insights into human cancers but also would provide useful guidance for its prevention and control and for prediction of future cancer cases.

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Cites work

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Cited in

(5)

• Studying health histories of cancer: A new model connecting cancer incidence and survival
• Widespread Immunity to Breast and Prostate Cancers is Predicted by a Novel Model that also Determines Sporadic and Hereditary Susceptible Population Sizes
• Stochastic and state space models of carcinogenesis: some new modeling approaches
• Genetic Susceptibility to Prostate, Breast, and Colorectal Cancer among Nordic Twins
• A mixed model of carcinogenesis with applications to retinoblastoma

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