Rapid emergence of co-colonization with community-acquired and hospital-acquired methicillin-resistant staphylococcus aureus strains in the hospital setting

DOI10.1051/MMNP/20105306zbMATH Open1193.92051arXiv0906.3319OpenAlexW2141336519WikidataQ34081029 ScholiaQ34081029MaRDI QIDQ3562963FDOQ3562963

Authors: E. M. C. D'Agata, Joanna Pressley, Glenn Webb 

Publication date: 28 May 2010

Published in: Mathematical Modelling of Natural Phenomena (Search for Journal in Brave)

Abstract: Background: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), a novel strain of MRSA, has recently emerged and rapidly spread in the community. Invasion into the hospital setting with replacement of the hospital-acquired MRSA (HA-MRSA) has also been documented. Co-colonization with both CA-MRSA and HA-MRSA would have important clinical implications given differences in antimicrobial susceptibility profiles and the potential for exchange of genetic information. Methods: A deterministic mathematical model was developed to characterize the transmission dynamics of HA-MRSA and CA-MRSA in the hospital setting and to quantify the emergence of co-colonization with both strains. Results: The model analysis shows that the state of co-colonization becomes endemic over time and that there is no competitive exclusion of either strain. Increasing the length of stay or rate of hospital entry among patients colonized with CA-MRSA leads to a rapid increase in the co-colonized state. Compared to MRSA decolonization strategy, improving hand hygiene compliance has the greatest impact on decreasing the prevalence of HA-MRSA, CA-MRSA and the co-colonized state. Conclusions: The model predicts that with the expanding community reservoir of CA-MRSA, the majority of hospitalized patients will become colonized with both CA-MRSA and HA-MRSA.

Full work available at URL: https://arxiv.org/abs/0906.3319

Recommendations

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• Modeling of Community- and Hospital-acquired Methicillin-resistant Staphylococcus Aureus Transmission in Hospital Settings
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zbMATH Keywords

ordinary differential equationscommunitystaphylococcus aureushospitalco-colonizationmethicillin-resistance

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Dynamical systems in biology (37N25) Applications of functional analysis in biology and other sciences (46N60) Applications of boundary value problems involving ordinary differential equations (34B60)

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Cited In (11)

• Stationary solution of a stochastic nosocomial epidemic model in hospital intensive care units
• On the exponential stability of a stochastic model for transmission dynamics of antimicrobial-resistant infections
• Antibiotic resistance as collateral damage: the tragedy of the commons in a two-disease setting
• Fractional methicillin-resistant \textit{Staphylococcus aureus} infection model under Caputo operator
• Competition of hospital-acquired and community-acquired methicillin-resistantStaphylococcus aureusstrains in hospitals
• Control of Nipah virus outbreak in commercial pig-farm with biosecurity and culling
• The work of Glenn F. Webb
• Optimal control of methicillin-resistant \textit{Staphylococcus aureus} transmission in hospital settings
• Mathematical assessment of the impact of cohort vaccination on pneumococcal carriage and serotype replacement
• The effect of co-colonization with community-acquired and hospital-acquired methicillin-resistant \textit{Staphylococcus aureus} strains on competitive exclusion
• Individual based models and differential equations models of nosocomial epidemics in hospital intensive care units

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