On the MTD paradigm and optimal control for multi-drug cancer chemotherapy

DOI10.3934/MBE.2013.10.803MaRDI QIDQ356954zbMATH OpenOpenAlexWikidataFDO

Authors Heinz Schättler, Mostafa Reisi Gahrooi, Siamak Mahmoudian Dehkordi, Urszula Ledzewicz

Publication date 29 July 2013

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/mbe.2013.10.803

zbMATH Keywords

chemotherapyoptimal controlmulti-drug treatments

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15) Applications of optimal control and differential games (49N90)

Recommendations

• A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
• On optimal chemotherapy for heterogeneous tumors
• On drug resistance and metronomic chemotherapy: a mathematical modeling and optimal control approach
• A 3-compartment model for chemotherapy of heterogeneous tumor populations
• The influence of PK/PD on the structure of optimal controls in cancer chemotherapy models

Cited in

(16)

• Fields of extremals and sensitivity analysis for multi-input bilinear optimal control problems
• Sufficient conditions for strong local optimality in optimal control problems with \(L_{2}\)-type objectives and control constraints
• On drug resistance and metronomic chemotherapy: a mathematical modeling and optimal control approach
• Evaluating the efficacies of maximum tolerated dose and metronomic chemotherapies: a mathematical approach
• Optimal Chemotherapy for Brain Tumor Growth in a Reaction-Diffusion Model
• Optimizing the delivery of combination therapy for tumors: A mathematical model
• Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme?
• Minimizing long-term tumor burden: the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis
• A 3-compartment model for chemotherapy of heterogeneous tumor populations
• Dynamics and optimal control of chemotherapy for low grade gliomas: insights from a mathematical model
• Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
• The structure of optimal protocols for a mathematical model of chemotherapy with antiangiogenic effects
• A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
• Influence of mutations in phenotypically-structured populations in time periodic environment
• Optimal treatments for photodynamic therapy
• Optimal control problems for differential equations applied to tumor growth: state of the art

This page was built for publication: On the MTD paradigm and optimal control for multi-drug cancer chemotherapy

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q356954)