Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials

DOI10.1111/j.1541-0420.2009.01302.xzbMath1192.62224WikidataQ33945668 ScholiaQ33945668MaRDI QIDQ3576931

Peter F. Thall, Hoang Q. Nguyen, Andrew Kramar, Xavier Paoletti, Nadine Houede

Publication date: 3 August 2010

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc2893272

zbMATH Keywords

utility; clinical trial; adaptive design; Bayesian design; combination dose finding

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

62F15: Bayesian inference

92C50: Medical applications (general)