Endogenous circannual rhythm in luteinizing hormone secretion: insight from signal analysis coupled with mathematical modelling

DOI10.1098/RSTA.2009.0136zbMATH Open1192.94058arXiv0903.1698OpenAlexW3124196811WikidataQ39559598 ScholiaQ39559598MaRDI QIDQ3579059FDOQ3579059

Authors: Alexandre Vidal, Claire Médigue, Benoît Malpaux, Frédérique Clément 

Publication date: 5 August 2010

Published in: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (Search for Journal in Brave)

Abstract: In sheep as in many vertebrates, the seasonal pattern of reproduction is timed by the annual photoperiodic cycle, characterized by seasonal changes in the daylength. The photoperiodic information is translated into a circadian profile of melatonin secretion. After multiple neuronal relays (within the hypothalamus), melatonin impacts GnRH (gonadotrophin releasing hormone) secretion that in turn controls ovarian cyclicity. The pattern of GnRH secretion is mirrored into that of LH (luteinizing hormone) secretion, whose plasmatic level can be easily measured. We addressed the question of whether there exists an endogenous circannual rhythm in a tropical sheep population that exhibits clear seasonal ovarian activity when ewes are subjected to temperate latitudes. We based our analysis on LH time series collected in the course of 3 years from ewes subjected to a constant photoperiodic regime. Due to intra- and inter- animal variability and unequal sampling times, the existence of an endogenous rhythm is not straightforward. We have used time-frequency signal processing methods to extract hidden rhythms from the data. To further investigate the LF (low frequency) and HF (high frequency) components of the signals, we have designed a mathematical model of LH plasmatic level accounting for the effect of experimental sampling times. The model enables us to confirm the existence of an endogenous circannual rhythm, to investigate the action mechanism of photoperiod on the pulsatile pattern of LH secretion (control of the interpulse interval) and to conclude that the HF component is mainly due to the experimental sampling protocol.

Full work available at URL: https://arxiv.org/abs/0903.1698

Recommendations

• A mathematical model for the actions of activin, inhibin, and follistatin on pituitary gonado\-trophs
• A mathematical model for the mammalian melatonin rhythm
• Volley-like male GH secretion indicates existence of an intrinsic \(1-h\) oscillator in the hypothalamus
• Mathematical Modeling of the GnRH Pulse and Surge Generator
• A NONLINEAR MATHEMATICAL MODEL FOR PULSATILE DISCHARGES OF LUTEINIZING HORMONE MEDIATED BY HYPOTHALAMIC AND EXTRA-HYPOTHALAMIC PATHWAYS

zbMATH Keywords

time-frequency analysismathematical modellingchronobiologyendogenous reproductive rhythm

Mathematics Subject Classification ID

Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Signal theory (characterization, reconstruction, filtering, etc.) (94A12) Physiology (general) (92C30) Biological rhythms and synchronization (92B25)

Cited In (3)

• A NONLINEAR MATHEMATICAL MODEL FOR PULSATILE DISCHARGES OF LUTEINIZING HORMONE MEDIATED BY HYPOTHALAMIC AND EXTRA-HYPOTHALAMIC PATHWAYS
• A note on semi-discrete modelling in the life sciences
• Title not available (Why is that?)

This page was built for publication: Endogenous circannual rhythm in luteinizing hormone secretion: insight from signal analysis coupled with mathematical modelling

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3579059)