Non-Gaussian dynamics of a tumor growth system with immunization

DOI10.3934/IPI.2013.7.697zbMATH Open1272.92025arXiv1207.5890OpenAlexW2962746934MaRDI QIDQ371077FDOQ371077

Authors: Mengli Hao, Ting Gao, Wei Xu, Jinqiao Duan 

Publication date: 27 September 2013

Published in: Inverse Problems and Imaging (Search for Journal in Brave)

Abstract: This paper is devoted to exploring the effects of non-Gaussian fluctuations on dynamical evolution of a tumor growth model with immunization, subject to non-Gaussian {alpha}-stable type L'evy noise. The corresponding deterministic model has two meaningful states which represent the state of tumor extinction and the state of stable tumor, respectively. To characterize the lifetime for different initial densities of tumor cells staying in the domain between these two states and the likelihood of crossing this domain, the mean exit time and the escape probability are quantified by numerically solving differential integral equations with appropriate exterior boundary conditions. The relationships between the dynamical properties and the noise parameters are examined. It is found that in the different stages of tumor, the noise parameters have different influence on the lifetime and the likelihood inducing tumor extinction. These results are relevant for determining efficient therapeutic regimes to induce the extinction of tumor cells.

Full work available at URL: https://arxiv.org/abs/1207.5890

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zbMATH Keywords

escape probabilitymean exit timestochastic dynamics of tumor growthLévy jump measurenon-Gaussian Lévy process

Mathematics Subject Classification ID

Medical applications (general) (92C50) Probabilistic models, generic numerical methods in probability and statistics (65C20) Applications of stochastic analysis (to PDEs, etc.) (60H30) Stochastic processes (60G99)

Cited In (10)

• Analysis of mathematical model of prostate cancer with androgen deprivation therapy
• Asymmetric non-Gaussian effects in a tumor growth model with immunization
• The properties of the anti-tumor model with coupling non-Gaussian noise and Gaussian colored noise
• Effect of non-immunogenic microenvironmental factors on tumor growth dynamics modeled by correlated noises in the presence of immune response
• Mean exit time and escape probability for a tumor growth system under non-Gaussian noise
• Extinction effects of multiplicative non-Gaussian Lévy noise in a tumor growth system with immunization
• Gaussian and non-Gaussian colored noise induced escape in a tumor-immune model
• Tumor stabilization induced by t-cell recruitment fluctuations
• Stochastic bifurcation for a tumor-immune system with symmetric Lévy noise
• Nonlocal dynamics for non-Gaussian systems arising in biophysical modeling

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