Theoretical foundations for traditional and generalized sensitivity functions for nonlinear delay differential equations

DOI10.3934/MBE.2013.10.1301MaRDI QIDQ374243zbMATH OpenOpenAlexWikidataFDO

Authors Danielle Robbins, Karyn L. Sutton, H. Thomas Banks

Publication date 23 October 2013

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/mbe.2013.10.1301

zbMATH Keywords

sensitivityFisher information matrixgeneralized sensitivitydelay equationsdifferentiability with respect to delays

Mathematics Subject Classification ID

Qualitative investigation and simulation of models involving functional-differential equations (34K60) Sensitivity, stability, well-posedness (49K40) Inverse problems for functional-differential equations (34K29)

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(8)

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• Linear approximation in sensitivity theory for delayed dynamic models: Its validity
• Generalized sensitivity analysis for delay differential equations
• Parameter estimation of systems with delays via structural sensitivity analysis
• Delay stability of reaction systems
• Parametric sensitivity analysis of oscillatory delay systems with an application to gene regulation
• Optimal design of non-equilibrium experiments for genetic network interrogation

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