Theoretical analysis of kinesin KIF1A transport along microtubule

DOI10.1007/S10955-013-0804-YzbMATH Open1274.92018arXiv1105.2992OpenAlexW3102573250MaRDI QIDQ377772FDOQ377772

Authors: Yunxin Zhang 

Publication date: 7 November 2013

Published in: Journal of Statistical Physics (Search for Journal in Brave)

Abstract: Recently, a three-state model is presented to describe the intracellular traffic of unconventional (single-headed) kinesin KIF1A [Phys. Rev. Lett. {�f 95}, 118101 (2005)], in which each motor can bind strongly or weakly to its microtubule track, and each binding site of the track might be empty or occupied by one motor. As the usual two-state model, i.e. the totally asymmetric simple exclusion process (TASEP) with motor detachment and attachment, in steady state of the system, this three-state model also exhibits shock (or domain wall separating the high-density and low density phases) and boundary layers. In this study, using mean-field analysis, the conditions of existence of shock and boundary layers are obtained theoretically. Combined with numerical calculations, the properties of shock are also studied. This study will be helpful to understand the biophysical properties of the collective transport of kinesin KIF1A.

Full work available at URL: https://arxiv.org/abs/1105.2992

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zbMATH Keywords

shockTASEPKIF1Amolecular motor

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Dynamical systems in biology (37N25) Classical flows, reactions, etc. in chemistry (92E20)

Cites Work

• Phase transitions in an exactly soluble one-dimensional exclusion process
• Exact solution of a 1D asymmetric exclusion model using a matrix formulation
• Exclusion processes with internal states
• Cluster-cluster aggregation as an analogue of a turbulent cascade: Kolmogorov phenomenology, scaling laws and the breakdown of self-similarity.

Cited In (3)

• Molecular mechanism of interaction between kinesin motors affecting their residence times on microtubule lattice and end
• Existence and uniqueness of solution of the differential equation describing the TASEP-LK coupled transport process
• From aggressive driving to molecular motor traffic

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