Optimal controls for a mathematical model of tumor-immune interactions under targeted chemotherapy with immune boost

DOI10.3934/DCDSB.2013.18.1031MaRDI QIDQ378951zbMATHOpenAlexFDO

Authors Mozhdeh Sadat Faraji Mosalman, Heinz Schättler, Urszula Ledzewicz

Publication date 12 November 2013

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/dcdsb.2013.18.1031

zbMATH Keywords

chemotherapyoptimal controlsingular controlsregions of attractiontumor-immune interactions

Mathematics Subject Classification ID

Medical applications (general) (92C50) Optimality conditions for problems involving ordinary differential equations (49K15) Applications of optimal control and differential games (49N90) Application models in control theory (93C95)

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• An optimal control approach to cancer treatment under immunological activity
• Optimal control problem for a general reaction-diffusion tumor-immune interaction system of mixed immunotherapy and chemotherapy
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• On the role of the objective in the optimization of compartmental models for biomedical therapies
• A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
• Optimal control analysis of combined chemotherapy-immunotherapy treatment regimens in a PKPD cancer evolution model
• Dynamical behaviour of a tumor-immune system with chemotherapy and optimal control
• On the optimal control problem for a model of the synergy of chemo‐ and immunotherapy
• Optimization of combination therapy for chronic myeloid leukemia with dosing constraints
• Optimal response to chemotherapy for a mathematical model of tumor-immune dynamics
• Bang-bang optimal controls for a mathematical model of chemo- and immunotherapy in cancer
• Dynamics of tumor-immune interaction under treatment as an optimal control problem
• Dynamical properties of a minimally parameterized mathematical model for metronomic chemotherapy
• Optimal control of cancer treatments: mathematical models for the tumor microenvironment
• Fastest time to cancer by loss of tumor suppressor genes

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