A computational model clarifies the roles of positive and negative feedback loops in the Droso\-phila circadian clock

DOI10.1016/J.PHYSLETA.2010.04.059MaRDI QIDQ415133zbMATH OpenOpenAlexFDO

Authors Jun-Wei Wang, Tianshou Zhou

Publication date 11 May 2012

Published in Physics Letters. A (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.physleta.2010.04.059

zbMATH Keywords

positive feedback looptranscriptional feedback loop

Mathematics Subject Classification ID

Biological rhythms and synchronization (92B25) Stabilization of systems by feedback (93D15)

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Cites work

• A mathematical model of the \textit{Drosophila} circadian clock with emphasis on posttranslational mechanisms
• Modelling of circadian rhythms in \textit{Drosophila} incorporating the interlocked PER/TIM and VRI/PDP1 feedback loops
• PER/TIM-mediated amplification, gene dosage effects and temperature compensation in an interlocking-feedback loop model of the \textit{Drosophila} circadian clock
• Uncovering the design principles of circadian clocks: mathematical analysis of flexibility and evolutionary goals

Cited in

(7)

• Modelling circadian rhythms in \textit{Drosophila} and investigation of VRI and PDP1 feedback loops using a new mathematical model
• A model of the cell-autonomous mammalian circadian clock
• Modelling of circadian rhythms in \textit{Drosophila} incorporating the interlocked PER/TIM and VRI/PDP1 feedback loops
• A mathematical model of the \textit{Drosophila} circadian clock with emphasis on posttranslational mechanisms
• PER/TIM-mediated amplification, gene dosage effects and temperature compensation in an interlocking-feedback loop model of the \textit{Drosophila} circadian clock
• Tick, tock, circadian clocks
• The trade-off mechanism in mammalian circadian clock model with two time delays

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