Diversity and virulence thresholds in AIDS.

DOI10.1073/PNAS.91.2.544MaRDI QIDQ4282415zbMATH OpenOpenAlexWikidataFDO

Authors Rob J. De Boer, Maarten C. Boerlijst

Publication date 17 April 1994

Published in Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1073/pnas.91.2.544

zbMATH Keywords

incubation periodbifurcationhuman immunodeficiency virusimmune systeminteractionvirulencebasins of attractionseparatrixordinary differential equations modelstable steady stateinfectivityantigenicity\(T\) lymphocytesAIDS diversity thresholddiversity thresholdstable manifold of a saddle point

Mathematics Subject Classification ID

Medical epidemiology (92C60) Epidemiology (92D30)

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• Assessing Effects of HIV Heterogeneity and Macrophage on the HIV Pathogenesis in HIV-Infected Individuals
• Analysis of equilibrium positions for a system that describes the interaction of viruses with the immune system
• Virus load and antigenic diversity
• Immune impairment in HIV infection: existence of risky and immunodeficiency thresholds
• Dynamic aspects of tumour–immune system interaction under a periodic immunotherapy
• A Mathematical Model of Continuous HIV Mutations Eluding Immune Defence
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• THE COUPLED WITHIN-AND BETWEEN-HOST DYNAMICS IN THE EVOLUTION OF HIV/AIDS IN CHINA
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• Contribution of HIV-1 genomes that do not integrate to the basic reproductive ratio of the virus
• Gene therapy of T helper cells in HIV infection: Mathematical model of the criteria for clinical effect

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