Efficacy Evaluation for Monotherapies in Two-by-Two Factorial Trials

DOI10.2307/2533278MaRDI QIDQ4335648zbMATH OpenOpenAlexWikidataFDO

Authors H. M. James Hung, G. Y. H. Chi, R. T. O'Neill

Publication date 26 August 1997

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2307/2533278

zbMATH Keywords

always-pooled statisticbiasfactorial clinical trialsmaximum test statisticmean square errormonotherapy treatmentsnever-pooled statisticspooled testpowerpreliminary test of treatment interactiontwo-stage statistic

Mathematics Subject Classification ID

Factorial statistical designs (62K15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• Bayesian Design and Analysis of Two x Two Factorial Clinical Trials
• Analysis of Factorial Survival Experiments
• The impact of a preliminary test for interaction in a 2 × 2 factorial trial
• Qualitative Interactions in Multifactor Studies

Cited in

(7)

• Confidence intervals in regression utilizing prior information
• Understanding on the pooled test for controlled clinical trials
• On Determining the Effects of Therapy on Disease Damage in Non Randomized Studies with Multiple Treatments: A Study of Juvenile Myositis
• Qualitative Interactions in Multifactor Studies
• Bayesian Design and Analysis of Two x Two Factorial Clinical Trials
• The impact of a preliminary test for interaction in a 2 × 2 factorial trial
• Economic evaluation of factorial randomised controlled trials: challenges, methods and recommendations

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