Interim analyses and early termination of clinical trials

DOI10.1080/10543409708835205zbMATH Open0908.62109OpenAlexW2069870586WikidataQ41633566 ScholiaQ41633566MaRDI QIDQ4390771FDOQ4390771

Authors: Sung C. Choi 

Publication date: 15 March 1999

Published in: Journal of Biopharmaceutical Statistics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/10543409708835205

Recommendations

• Interim and terminal analyses of clinical trials with failure-time endpoints and related group sequential designs
• Futility stopping in clinical trials
• An overview of sequential methods and their application in clinical trials
• Incorporation of a stopping criterion for futility into the design of a clinical trial with one interim analysis
• Statistical approaches to interim monitoring of medical trials: A review and commentary

zbMATH Keywords

clinical trialsearly terminationdelayed observationsgroup sequential testsinterim analysesfutility analyses

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical analysis (62L10)

Cites Work

• Discrete Sequential Boundaries for Clinical Trials
• Stochastically curtailed tests in long–term clinical trials
• Sequential Analysis with Delayed Observations
• Monitoring Clinical Trials Based on Predictive Probability of Significance

Cited In (5)

• Early Stopping by Using Stochastic Curtailment in a Three-Arm Sequential Trial
• Interim and terminal analyses of clinical trials with failure-time endpoints and related group sequential designs
• A note on penalty-free interim analyses of clinical studies with binary responses
• Futility stopping in clinical trials
• Interphase Clinical Trials: Phase III/Phase IV

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