Multiple testing of local maxima for detection of peaks in 1D

DOI10.1214/11-AOS943zbMATH Open1246.62173arXiv1203.3063OpenAlexW1979083915WikidataQ39669975 ScholiaQ39669975MaRDI QIDQ450000FDOQ450000

Authors: Yulia Gavrilov, Robert J. Adler, Armin Schwartzman 

Publication date: 3 September 2012

Published in: The Annals of Statistics (Search for Journal in Brave)

Abstract: A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed sequence. Assuming unimodal true peaks with finite support and Gaussian stationary ergodic noise, it is shown that the algorithm with Bonferroni or Benjamini--Hochberg correction provides asymptotic strong control of the family wise error rate and false discovery rate, and is power consistent, as the search space and the signal strength get large, where the search space may grow exponentially faster than the signal strength. Simulations show that error levels are maintained for nonasymptotic conditions, and that power is maximized when the smoothing kernel is close in shape and bandwidth to the signal peaks, akin to the matched filter theorem in signal processing. The methods are illustrated in an analysis of electrical recordings of neuronal cell activity.

Full work available at URL: https://arxiv.org/abs/1203.3063

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zbMATH Keywords

false discovery rateGaussian processkernel smoothingmatched filtertopological inference

Mathematics Subject Classification ID

Statistical aspects of information-theoretic topics (62B10) Hypothesis testing in multivariate analysis (62H15) Paired and multiple comparisons; multiple testing (62J15)

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Cited In (26)

• Segmentation and estimation of change-point models: false positive control and confidence regions
• Expected number and height distribution of critical points of smooth isotropic Gaussian random fields
• Multiscale change-point segmentation: beyond step functions
• Multiple testing with the structure-adaptive Benjamini-Hochberg algorithm
• Multiple testing of local maxima for detection of peaks in random fields
• Testing over a continuum of null hypotheses with false discovery rate control
• False discovery variance reduction in large scale simultaneous hypothesis tests
• False discovery rate for functional data
• Modelling persistence diagrams with planar point processes, and revealing topology with bagplots
• Distribution of the height of local maxima of Gaussian random fields
• LandScape: a simple method to aggregate \(p\)-values and other stochastic variables without a priori grouping
• Multiple testing of local maxima for detection of peaks on the (celestial) sphere
• FDR control of detected regions by multiscale matched filtering
• A multi-scale approach for testing and detecting peaks in time series
• Scan statistic tail probability assessment based on process covariance and window size
• Multiple testing of local extrema for detection of change points
• Semiparametric Bayesian Inference for Local Extrema of Functions in the Presence of Noise
• Scan statistics analysis for detection of introns in time-course tiling array data
• A shape-based cutting and clustering algorithm for multiple change-point detection
• Multiple testing of local maxima for detection of peaks in ChIP-Seq data
• Intensity estimation of non-homogeneous Poisson processes from shifted trajectories
• A peeling algorithm for multiple testing on a random field
• A region-based multiple testing method for hypotheses ordered in space or time
• Multidimensional multiscale scanning in exponential families: limit theory and statistical consequences
• The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation
• Selection-corrected statistical inference for region detection with high-throughput assays

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