Multiple testing of local maxima for detection of peaks in 1D
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Abstract: A topological multiple testing scheme for one-dimensional domains is proposed where, rather than testing every spatial or temporal location for the presence of a signal, tests are performed only at the local maxima of the smoothed observed sequence. Assuming unimodal true peaks with finite support and Gaussian stationary ergodic noise, it is shown that the algorithm with Bonferroni or Benjamini--Hochberg correction provides asymptotic strong control of the family wise error rate and false discovery rate, and is power consistent, as the search space and the signal strength get large, where the search space may grow exponentially faster than the signal strength. Simulations show that error levels are maintained for nonasymptotic conditions, and that power is maximized when the smoothing kernel is close in shape and bandwidth to the signal peaks, akin to the matched filter theorem in signal processing. The methods are illustrated in an analysis of electrical recordings of neuronal cell activity.
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Cites work
- scientific article; zbMATH DE number 49909 (Why is no real title available?)
- scientific article; zbMATH DE number 720689 (Why is no real title available?)
- scientific article; zbMATH DE number 3259552 (Why is no real title available?)
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- Testing over a continuum of null hypotheses with false discovery rate control
- False discovery variance reduction in large scale simultaneous hypothesis tests
- False discovery rate for functional data
- Modelling persistence diagrams with planar point processes, and revealing topology with bagplots
- Distribution of the height of local maxima of Gaussian random fields
- LandScape: a simple method to aggregate \(p\)-values and other stochastic variables without a priori grouping
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- A shape-based cutting and clustering algorithm for multiple change-point detection
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- Intensity estimation of non-homogeneous Poisson processes from shifted trajectories
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- The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation
- Multidimensional multiscale scanning in exponential families: limit theory and statistical consequences
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