Simulation of arrhythmogenic effect of rogue RyRs in failing heart by using a coupled model

DOI10.1155/2012/183978MaRDI QIDQ454622zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Luyao Lu, Ling Xia, Xiuwei Zhu

Publication date 10 October 2012

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1155/2012/183978

zbMATH Keywords

cardiac cellsheart failurerogue RyRsspatiotemporal Ca\(^{2+}\) reaction-diffusion system

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Cell biology (92C37)

Review text

Summary: Cardiac cells with heart failure are usually characterized by impairment of Ca\(^{2+}\) handling with smaller SR Ca\(^{2+}\) store and high risk of triggered activities. In this study, we developed a coupled model by integrating the spatiotemporal Ca\(^{2+}\) reaction-diffusion system into the cellular electrophysiological model. With the coupled model, the subcellular Ca\(^{2+}\) dynamics and global cellular electrophysiology could be simultaneously traced. The proposed coupled model was then applied to study the effects of rogue RyRs on Ca\(^{2+}\) cycling and membrane potential in failing heart. The simulation results suggested that, in the presence of rogue RyRs, Ca\(^{2+}\) dynamics is unstable and Ca\(^{2+}\) waves are prone to be initiated spontaneously. These release events would elevate the membrane potential substantially which might induce delayed afterdepolarizations or triggered action potentials. Moreover, the variation of membrane potential depolarization is indicated to be dependent on the distribution density of rogue RyR channels. This study provides a new possible arrhythmogenic mechanism for heart failure from subcellular to cellular level.

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Cited in

(1)

• Computational modelling of the initiation and development of spontaneous intracellular \(Ca^{2+}\) waves in ventricular myocytes

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