Study of tumor growth under hyperthermia condition

DOI10.1155/2012/198145MaRDI QIDQ454630zbMATH OpenOpenAlexWikidataFDO

Authors Qing Zhu, Aili Zhang, Lisa X. Xu, Ping Liu

Publication date 10 October 2012

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1155/2012/198145

zbMATH Keywords

cellular metabolismcontrolling tumor growthhyperthermia conditionWarburg effect

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Review text

Summary: The new concept of keeping primary tumor under control in situ to suppress distant foci sheds light on the treatment of metastatic tumor. Hyperthermia is considered as one of the means for controlling tumor growth. To simulate the tumor growth, a continuum mathematical model has been introduced. The newest understanding of the Warburg effect on the cellular metabolism and diffusion of the nutrients in the tissue has been taken into consideration. The numerical results are compared with the in vivo experimental data by fitting the tumor cell doubling time/tumor cell growth rate under different thermal conditions. Both the tumor growth curve and corresponding average glucose concentration have been predicted. The numerical results have quantitatively illustrated the controlling effect on tumor growth under hyperthermia condition in the initial stage.

Recommendations

• A computational study of combination HIFU-chemotherapy as a potential means of overcoming cancer drug resistance
• Mathematical modelling of tumour growth and treatment
• Heat transfer in tissue containing a prevascular tumor
• scientific article; zbMATH DE number 1067055
• On a non-isothermal Cahn-Hilliard model for tumor growth

Cites work

• A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion
• A mathematical model for the growth and classification of a solid tumor: A new approach via nonlinear elasticity theory using strain-energy functions
• A new mathematical model for avascular tumour growth
• Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development
• Continuous and discrete mathematical models of tumor-induced angiogenesis
• Growth of nonnecrotic tumors in the presence and absence of inhibitors
• scientific article; zbMATH DE number 1320551 (Why is no real title available?)
• scientific article; zbMATH DE number 1005391 (Why is no real title available?)
• Interaction of tumor with its micro-environment: a mathematical model
• Mathematical Models of Avascular Tumor Growth
• Models for the Growth of a Solid Tumor by Diffusion
• Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications
• Multiscale modelling and nonlinear simulation of vascular tumour growth

Cited in

(1)

• Optimizing breast cancer treatment using hyperthermia: a single and multi-objective optimal control approach

This page was built for publication: Study of tumor growth under hyperthermia condition

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q454630)