Sample size growth with an increasing number of comparisons

DOI10.1155/2012/935621MaRDI QIDQ454818zbMATH OpenOpenAlexWikidataFDO

Authors Chi-Hong Tseng, Yongzhao Shao

Publication date 10 October 2012

Published in Journal of Probability and Statistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2012/935621

Mathematics Subject Classification ID

Paired and multiple comparisons; multiple testing (62J15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Review text

Summary: An appropriate sample size is crucial for the success of many studies that involve a large number of comparisons. Sample size formulas for testing multiple hypotheses are provided in this paper. They can be used to determine the sample sizes required to provide adequate power while controlling familywise error rate or false discovery rate, to derive the growth rate of sample sizes with respect to an increasing number of comparisons or decrease in effective sizes, and to assess the reliability of study designs. It is demonstrated that practical sample sizes can often be achieved even when adjustments for a large number of comparisons are made as in many genomewide studies.

Recommendations

• Sample size determination in step-down and step-up multiple tests for comparing treatments with a control
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• Sample size for simultaneous testing of rate differences in non-inferiority trials with multiple endpoints
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Cites work

• A Direct Approach to False Discovery Rates
• scientific article; zbMATH DE number 720689 (Why is no real title available?)
• scientific article; zbMATH DE number 765034 (Why is no real title available?)
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• Multiple Comparisons
• Resampling-based multiple testing for microarray data analysis (With comments)
• Statistical significance for genomewide studies

Cited in

(1)

• Sample size determination for the confidence interval of mean comparison adjusted by multiple covariates

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