Bifurcations in valveless pumping techniques from a coupled fluid-structure-electrophysiology model in heart development

DOI10.11145/J.BIOMATH.2017.11.297zbMATH Open1406.92129arXiv1709.05264OpenAlexW2755751087MaRDI QIDQ4556249FDOQ4556249

Authors: Nicholas A. Battista, L. A. Miller 

Publication date: 23 November 2018

Published in: Biomath (Search for Journal in Brave)

Abstract: We explore an embryonic heart model that couples electrophysiology and muscle-force generation to flow induced using a $2D$ fluid-structure interaction framework based on the immersed boundary method. The propagation of action potentials are coupled to muscular contraction and hence the overall pumping dynamics. In comparison to previous models, the electro-dynamical model does not use prescribed motion to initiate the pumping motion, but rather the pumping dynamics are fully coupled to an underlying electrophysiology model, governed by the FitzHugh-Nagumo equations. Perturbing the diffusion parameter in the FitzHugh-Nagumo model leads to a bifurcation in dynamics of action potential propagation. This bifurcation is able to capture a spectrum of different pumping regimes, with dynamic suction pumping and peristaltic-like pumping at the extremes. We find that more bulk flow is produced within the realm of peristaltic-like pumping.

Full work available at URL: https://arxiv.org/abs/1709.05264

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zbMATH Keywords

fluid-structure interactionimmersed boundary methodmathematical biologybiomechanicsvalveless pumpingheart development

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biomechanics (92C10) Physiological flow (92C35)

Cited In (4)

• Morphomechanical Model of the Torsional C-Looping in the Embryonic Heart
• Neuromechanical pumping: boundary flexibility and traveling depolarization waves drive flow within valveless, tubular hearts
• Fluid dynamics in heart development: effects of hematocrit and trabeculation
• Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands

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