Bifurcations in valveless pumping techniques from a coupled fluid-structure-electrophysiology model in heart development

DOI10.11145/J.BIOMATH.2017.11.297MaRDI QIDQ4556249zbMATH OpenOpenAlexFDO

Authors Nicholas A. Battista, L. A. Miller

Publication date 23 November 2018

Published in Biomath (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1709.05264

zbMATH Keywords

fluid-structure interactionimmersed boundary methodmathematical biologybiomechanicsvalveless pumpingheart development

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Biomechanics (92C10) Physiological flow (92C35)

Abstract: We explore an embryonic heart model that couples electrophysiology and muscle-force generation to flow induced using a $2D$ fluid-structure interaction framework based on the immersed boundary method. The propagation of action potentials are coupled to muscular contraction and hence the overall pumping dynamics. In comparison to previous models, the electro-dynamical model does not use prescribed motion to initiate the pumping motion, but rather the pumping dynamics are fully coupled to an underlying electrophysiology model, governed by the FitzHugh-Nagumo equations. Perturbing the diffusion parameter in the FitzHugh-Nagumo model leads to a bifurcation in dynamics of action potential propagation. This bifurcation is able to capture a spectrum of different pumping regimes, with dynamic suction pumping and peristaltic-like pumping at the extremes. We find that more bulk flow is produced within the realm of peristaltic-like pumping.

Recommendations

• Neuromechanical pumping: boundary flexibility and traveling depolarization waves drive flow within valveless, tubular hearts
• Fluid dynamics in heart development: effects of hematocrit and trabeculation
• Flow within models of the vertebrate embryonic heart
• Computational models of valveless pumping using the immersed boundary method
• On the dynamic suction pumping of blood cells in tubular hearts

Cited in

(4)

• Morphomechanical Model of the Torsional C-Looping in the Embryonic Heart
• Neuromechanical pumping: boundary flexibility and traveling depolarization waves drive flow within valveless, tubular hearts
• Fluid dynamics in heart development: effects of hematocrit and trabeculation
• Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands

This page was built for publication: Bifurcations in valveless pumping techniques from a coupled fluid-structure-electrophysiology model in heart development

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4556249)