Computed flow and fluorescence over the ocular surface

DOI10.1093/IMAMMB/DQX011zbMATH Open1404.92071arXiv1610.10021OpenAlexW2963374483WikidataQ47647154 ScholiaQ47647154MaRDI QIDQ4559658FDOQ4559658

Authors: Longfei Li, Richard J. Braun, P. E. King-Smith, William D. Henshaw 

Publication date: 4 December 2018

Published in: Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Abstract: Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical model for tear film flow, evaporation, solutal transport and fluorescence over the exposed ocular surface during the interblink. Transport of the fluorescein ion by fluid flow in the tear film affects the intensity of fluorescence via changes in concentration and tear film thickness. Evaporation causes increased osmolarity and potential irritation over the ocular surface; it also alters fluorescein concentration and thus fluorescence. Using thinning rates from in vivo measurements together with thin film equations for flow and transport of multiple solutes, we compute dynamic results for tear film quantities of interest. We compare our computed intensity distributions with in vivo observations. A number of experimental features are recovered by the model.

Full work available at URL: https://arxiv.org/abs/1610.10021

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zbMATH Keywords

dry eyetear filmthin filmfluorescence imagingtear osmolaritytear breakup

Mathematics Subject Classification ID

Biological applications of optics and electromagnetic theory (78A70) Physiological flows (76Z05) Physiological flow (92C35)

Cited In (8)

• The tear film: pathological conditions
• On modeling tear breakup dynamics with a nematic lipid layer
• Title not available (Why is that?)
• Numerical methods for fourth-order PDEs on overlapping grids with application to Kirchhoff-Love plates
• On tear film breakup (TBU): dynamics and imaging
• Computed tear film and osmolarity dynamics on an eye-shaped domain
• Dynamics of fluorescent imaging for rapid tear thinning
• Dynamics and mechanisms for tear breakup (TBU) on the ocular surface

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