Computed flow and fluorescence over the ocular surface

DOI10.1093/IMAMMB/DQX011MaRDI QIDQ4559658zbMATH OpenOpenAlexWikidataFDO

Authors Longfei Li, Richard J. Braun, P. E. King-Smith, William D. Henshaw

Publication date 4 December 2018

Published in Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1610.10021

zbMATH Keywords

dry eyetear filmthin filmfluorescence imagingtear osmolaritytear breakup

Mathematics Subject Classification ID

Biological applications of optics and electromagnetic theory (78A70) Physiological flows (76Z05) Physiological flow (92C35)

Abstract: Fluorescein is perhaps the most commonly used substance to visualize tear film thickness and dynamics; better understanding of this process aids understanding of dry eye syndrome which afflicts millions of people. We study a mathematical model for tear film flow, evaporation, solutal transport and fluorescence over the exposed ocular surface during the interblink. Transport of the fluorescein ion by fluid flow in the tear film affects the intensity of fluorescence via changes in concentration and tear film thickness. Evaporation causes increased osmolarity and potential irritation over the ocular surface; it also alters fluorescein concentration and thus fluorescence. Using thinning rates from in vivo measurements together with thin film equations for flow and transport of multiple solutes, we compute dynamic results for tear film quantities of interest. We compare our computed intensity distributions with in vivo observations. A number of experimental features are recovered by the model.

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Cited in

(8)

• The tear film: pathological conditions
• On modeling tear breakup dynamics with a nematic lipid layer
• scientific article; zbMATH DE number 2100404 (Why is no real title available?)
• Numerical methods for fourth-order PDEs on overlapping grids with application to Kirchhoff-Love plates
• On tear film breakup (TBU): dynamics and imaging
• Computed tear film and osmolarity dynamics on an eye-shaped domain
• Dynamics of fluorescent imaging for rapid tear thinning
• Dynamics and mechanisms for tear breakup (TBU) on the ocular surface

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