Well-posedness of a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport

DOI10.1017/S0956792516000292zbMATH Open1375.92011arXiv1511.06143OpenAlexW2962777676MaRDI QIDQ4594640FDOQ4594640

Authors: Harald Garcke, Kei Fong Lam 

Publication date: 24 November 2017

Published in: European Journal of Applied Mathematics (Search for Journal in Brave)

Abstract: We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transport. We establish well-posedness results for the tumour model and a variant with a quasi-static nutrient. It will turn out that the presence of the source terms in the Cahn--Hilliard equation leads to new difficulties when one aims to derive a priori estimates. However, we are able to prove continuous dependence on initial and boundary data for the chemical potential and for the order parameter in strong norms.

Full work available at URL: https://arxiv.org/abs/1511.06143

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zbMATH Keywords

Cahn-Hilliard equationchemotaxisreaction-diffusion equationsweak solutionswell-posednesstumour growthphase field model

Mathematics Subject Classification ID

Medical applications (general) (92C50) Dependence of solutions to PDEs on initial and/or boundary data and/or on parameters of PDEs (35B30) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

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Cited In (73)

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