Missing value estimation for microarray data by Bayesian principal component analysis and iterative local least squares

MaRDI QIDQ459576zbMATH OpenFDO

Authors Fuxi Shi, Dan Zhang, Hamid Reza Karimi, Jun Chen

Publication date 13 October 2014

Published in Mathematical Problems in Engineering (Search for Journal in Brave)

Mathematics Subject Classification ID

Bayesian inference (62F15) Factor analysis and principal components; correspondence analysis (62H25)

Review text

Summary: Missing values are prevalent in microarray data, they course negative influence on downstream microarray analyses, and thus they should be estimated from known values. We propose a BPCA-iLLS method, which is an integration of two commonly used missing value estimation methods-Bayesian principal component analysis (BPCA) and local least squares (LLS). The inferior row-average procedure in LLS is replaced with BPCA, and the least squares method is put into an iterative framework. Comparative result shows that the proposed method has obtained the highest estimation accuracy across all missing rates on different types of testing datasets.

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(7)

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