An evaluation of common methods for dichotomization of continuous variables to discriminate disease status

DOI10.1080/03610926.2016.1248783MaRDI QIDQ4595869zbMATH OpenOpenAlexWikidataFDO

Authors

Publication date 6 December 2017

Published in Communications in Statistics: Theory and Methods (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc6020169

zbMATH Keywords

bioinformaticschi-squaredichotomizationdisease interactionsepigeneticskappa statisticmethod evaluationrelative riskYouden's Gini indexYouden's statistics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) General biostatistics (92B15)

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(6)

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• Dichotomous transformations for statistical inference about odds ratios
• Dichotomizing a continuous baseline covariate in randomized clinical trials with binary outcomes
• Optimal dichotomization of bimodal Gaussian mixtures
• Statistical relationship between quantitative and dichotomous variables: student's test and moving average approach
• A comparison of joint dichotomization and single dichotomization of interacting variables to discriminate a disease outcome

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