Dynamic predictions with time-dependent covariates in survival analysis using joint modeling and landmarking
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Publication:4597918
DOI10.1002/BIMJ.201600238zbMATH Open1379.62083arXiv1306.6479OpenAlexW1556637198WikidataQ38632584 ScholiaQ38632584MaRDI QIDQ4597918FDOQ4597918
Authors: Dimitris Rizopoulos, Geert Molenberghs, Emmanuel Lesaffre 
Publication date: 14 December 2017
Published in: Biometrical Journal (Search for Journal in Brave)
Abstract: A key question in clinical practice is accurate prediction of patient prognosis. To this end, nowadays, physicians have at their disposal a variety of tests and biomarkers to aid them in optimizing medical care. These tests are often performed on a regular basis in order to closely follow the progression of the disease. In this setting it is of medical interest to optimally utilize the recorded information and provide medically-relevant summary measures, such as survival probabilities, that will aid in decision making. In this work we present and compare two statistical techniques that provide dynamically-updated estimates of survival probabilities, namely landmark analysis and joint models for longitudinal and time-to-event data. Special attention is given to the functional form linking the longitudinal and event time processes, and to measures of discrimination and calibration in the context of dynamic prediction.
Full work available at URL: https://arxiv.org/abs/1306.6479
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Time series, auto-correlation, regression, etc. in statistics (GARCH) (62M10) Reliability and life testing (62N05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Measures of association (correlation, canonical correlation, etc.) (62H20)
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