Approximate tests for the equality of two cumulative incidence functions of a competing risk

DOI10.1080/02331888.2017.1336171MaRDI QIDQ4600809zbMATH OpenOpenAlexFDO

Authors Dennis Dobler, Markus Pauly

Publication date 12 January 2018

Published in Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1402.2209

zbMATH Keywords

wild bootstrapAalen-Johansen estimatorcompeting riskcumulative incidence functionapproximation techniques

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Asymptotic properties of nonparametric inference (62G20) Censored data models (62N01) Markov processes: hypothesis testing (62M02) Functional limit theorems; invariance principles (60F17)

Abstract: In the context of the widely used competing risks set-up we discuss different inference procedures for testing equality of two cumulative incidence functions, where the data may be subject to independent right-censoring or left-truncation. To this end we compare two-sample Kolmogorov-Smirnov- and Cramer-von Mises-type test statistics. Since, in general, their corresponding asymptotic limit distributions depend on unknown quantities, we utilize wild bootstrap resampling as well as approximation techniques to construct adequate test decisions. Here the latter procedures are motivated from testing procedures for heteroscedastic factorial designs but have not yet been proposed in the survival context. A simulation study shows the performance of all considered tests under various settings and finally a real data example about bloodstream infection during neutropenia is used to illustrate their application.

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Cited in

(6)

• Likelihood ratio tests for and against ordering of the cumulative incidence functions in multiple competing risks and discrete mark variable models
• Two-sample tests of the equality of two cumulative incidence functions
• A distribution-free test for the equality of failure rates due to two competing risks
• Comparing \(k\) cumulative incidence functions through resampling methods
• On testing the proportionality of two cumulative incidence functions in a competing risks setup
• An exact test for hazard similarity

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