Optimal chemotherapy and immunotherapy schedules for a cancer-obesity model with Caputo time fractional derivative

DOI10.1002/MMA.5298MaRDI QIDQ4614538zbMATH OpenOpenAlexWikidataFDO

Authors Tuğba Akman Yıldız, Sadia Arshad, D. Baleanu

Publication date 31 January 2019

Published in Mathematical Methods in the Applied Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1804.06259

zbMATH Keywords

cancer-obesity modelCaputo time fractional derivativechemotherapyfractional differential equationsimmunotherapyoptimal controlstability

Mathematics Subject Classification ID

Fractional ordinary differential equations (34A08) Dynamical systems in biology (37N25) Optimality conditions (49K99) Variational principles of physics (49S05) Numerical investigation of stability of solutions to ordinary differential equations (65L07) General biology and biomathematics (92B05) Neural biology (92C20) Medical applications (general) (92C50)

Abstract: This work presents a new mathematical model to depict the effect of obesity on cancerous tumor growth when chemotherapy as well as immunotherapy have been administered. We consider an optimal control problem to destroy the tumor population and minimize the drug dose over a finite time interval. The constraint is a model including tumor cells, immune cells, fat cells, chemotherapeutic and immunotherapeutic drug concentrations with Caputo time fractional derivative. We investigate the existence and stability of the equilibrium points namely, tumor free equilibrium and coexisting equilibrium, analytically. We discretize the cancer-obesity model using L1-method. Simulation results of the proposed model are presented to compare three different treatment strategies: chemotherapy, immunotherapy and their combination. In addition, we investigate the effect of the differentiation order $alpha$ and the value of the decay rate of the amount of chemotherapeutic drug to the value of the cost functional. We find out the optimal treatment schedule in case of chemotherapy and immunotherapy applied.

Recommendations

• New observations on optimal cancer treatments for a fractional tumor growth model with and without singular kernel
• Optimal control for cancer treatment mathematical model using Atangana-Baleanu-Caputo fractional derivative
• The role of obesity in fractional order tumor-immune model
• Optimal control of variable-order fractional model for delay cancer treatments
• A fractional-order delay differential model with optimal control for cancer treatment based on synergy between anti-angiogenic and immune cell therapies

Cited in

(17)

• Modelling and analysis of delayed tumour-immune system with hunting T-cells
• Stability analysis of fractional order mathematical model of tumor-immune system interaction
• An efficient algorithm for solving the fractional optimal control of SIRV epidemic model with a combination of vaccination and treatment
• Can fractional calculus help improve tumor growth models?
• A fractional-order delay differential model with optimal control for cancer treatment based on synergy between anti-angiogenic and immune cell therapies
• A mathematical model for the effect of obesity on cancer growth and on the immune system response
• Effects of the obesity on optimal control schedules of chemotherapy on a cancerous tumor
• Application of the Caputo‐Fabrizio and Atangana‐Baleanu fractional derivatives to mathematical model of cancer chemotherapy effect
• The role of obesity in fractional order tumor-immune model
• Modelling radiation cancer treatment with a death-rate term in ordinary and fractional differential equations
• A mathematical model with fractional-order dynamics for the combined treatment of metastatic colorectal cancer
• Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent
• Legendre wavelet method for solving variable-order nonlinear fractional optimal control problems with variable-order fractional Bolza cost
• Spectral analysis of matrices in B-spline Galerkin methods for Riesz fractional equations
• Optimal control problem on cancer-obesity dynamics
• Modeling the effects of obesity on a tumor-immune model with combined therapy
• Chaotic dynamics of a cancer model with singular and non-singular kernel

This page was built for publication: Optimal chemotherapy and immunotherapy schedules for a cancer-obesity model with Caputo time fractional derivative

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4614538)