Addressing small sample size bias in multiple‐biomarker trials: Inclusion of biomarker‐negative patients and Firth correction

DOI10.1002/bimj.201600226zbMath1387.62113WikidataQ47197037 ScholiaQ47197037MaRDI QIDQ4634690

Axel Benner, Christina Habermehl, Annette Kopp-Schneider

Publication date: 11 April 2018

Published in: Biometrical Journal (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1002/bimj.201600226

zbMATH Keywords

survival; Cox proportional hazards model; biomarkers; Firth correction; biomarker-negative patients; small sample size bias; umbrella trials

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

62N05: Reliability and life testing