scientific article; zbMATH DE number 1361721

MaRDI QIDQ4699463zbMATHFDO

Authors Jeffrey R. Eisele

Publication date 11 November 1999

zbMATH Keywords

restricted randomizationclinical trialexponential familiesinvariance principlesequential allocationmartingale central limit theoremsequential probability ratio test

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Asymptotic distribution theory in statistics (62E20) Sequential statistical design (62L05) Design of statistical experiments (62K99)

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• Doubly adaptive biased coin designs with heterogeneous responses
• Power efficiency of Efron's biased coin design
• Adaptive designs for sequential experiments
• Biased coin design with imbalance tolerance
• Properties of biased coin designs in sequential clinical trials
• A theoretical analysis of the power of biased coin designs
• Selecting a biased-coin design
• The power of Efron's biased coin design
• An adaptive biased coin design for the behrens-fisher problem

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