A model for enhanced and selective transport through biological membranes with alternating pores

DOI10.1016/J.MBS.2014.08.001MaRDI QIDQ472772zbMATH OpenOpenAlexWikidataFDO

Authors Daniele Andreucci, Dario Bellaveglia, Emilio N. M. Cirillo

Publication date 20 November 2014

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1402.7156

zbMATH Keywords

random walkFokker-Planck equationhomogenizationMonte Carlo methodalternating poresionic currents

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Biophysics (92C05)

Abstract: We investigate the outflux of ions through the channels in a cell membrane. The channels undergo an open/close cycle according to a periodic schedule. Our study is based both on theoretical considerations relying on homogenization theory, and on Monte Carlo numerical simulations. We examine the onset of a limiting boundary behavior characterized by a constant ratio between the outflux and the local density, in the thermodynamics limit. The focus here is on the issue of selectivity, that is on the different behavior of the ion currents through the channel in the cases of the selected and non-selected species.

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Cited in

(13)

• Fick and Fokker-Planck diffusion law in inhomogeneous media
• Model of active transport of ions through diatom cell biomembrane
• Diffusion in inhomogeneous media with periodic microstructures
• Residence time estimates for asymmetric simple exclusion dynamics on strips
• Effects of non-uniform occupancy on selective transport through nanochannels
• Models of blockage-induced selectivity
• Separation of biological ion in asymmetric nanochannels through alternating electric field
• scientific article; zbMATH DE number 5262808 (Why is no real title available?)
• Free to move or trapped in your group: mathematical modeling of information overload and coordination in crowded populations
• Diffusion through a cluster of small windows and flux regulation in microdomains
• An asymptotic study to explain the role of active transport in models with countercurrent exchangers
• Homogenization results for a class of parabolic equations with a non-local interface condition via time-periodic unfolding
• Homogenization of an alternating Robin-Neumann boundary condition via time-periodic unfolding

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