A prospective combination of phase II and phase III in drug development

DOI10.1007/BF03263544zbMath1301.62107OpenAlexW2070405587MaRDI QIDQ478229

Antonella Bacchieri, Adelchi Azzalini

Publication date: 3 December 2014

Published in: Metron (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/bf03263544

zbMATH Keywords

adaptive designsskew-normal distributionlikelihood-based inferenceconditional powerdrug development

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Sequential statistical design (62L05)

Related Items (6)

Some properties of the unified skew-normal distribution ⋮ Bayesian Conjugacy in Probit, Tobit, Multinomial Probit and Extensions: A Review and New Results ⋮ Expressions for moments of order statistics and records from the skew-normal distribution in terms of multivariate normal orthant probabilities ⋮ Records for time-dependent stationary Gaussian sequences ⋮ Unnamed Item ⋮ A closed-form filter for binary time series

Uses Software

• R

Cites Work

• Definition and probabilistic properties of skew-distributions.
• On the Unification of Families of Skew-normal Distributions
• Graphical models for skew‐normal variates
• Evaluation of Experiments with Adaptive Interim Analyses
• Phase 2 and 3 Combination Designs to Accelerate Drug Development

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