Catalog of the optimal controls in cancer chemotherapy for the Gompertz model depending on PK/PD and the integral constraint

DOI10.3934/DCDSB.2014.19.1563MaRDI QIDQ478655zbMATH OpenOpenAlexFDO

Authors Cecilia Pola, Luis Alberto Fernández

Publication date 4 December 2014

Published in Discrete and Continuous Dynamical Systems. Series B (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3934/dcdsb.2014.19.1563

zbMATH Keywords

optimal controlcancer chemotherapypharmacodynamicspharmacokineticssingular controls

Mathematics Subject Classification ID

Medical applications (general) (92C50) Numerical methods based on nonlinear programming (49M37) Optimality conditions for problems involving ordinary differential equations (49K15) Control/observation systems governed by ordinary differential equations (93C15) Numerical methods based on necessary conditions (49M05)

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Cites work

• scientific article; zbMATH DE number 1181255 (Why is no real title available?)
• scientific article; zbMATH DE number 3798532 (Why is no real title available?)
• scientific article; zbMATH DE number 932672 (Why is no real title available?)
• scientific article; zbMATH DE number 3204015 (Why is no real title available?)
• Algorithm 902: GPOPS: a MATLAB software for solving multiple-phase optimal control problems using the Gauss pseudospectral method
• An \(hp\)-adaptive pseudospectral method for solving optimal control problems
• An optimal control problem in cancer chemotherapy
• Modelling Physiological and Pharmacological Control on Cell Proliferation to Optimise Cancer Treatments
• On optimal delivery of combination therapy for tumors
• Optimal Control Applied to Competing Chemotherapeutic Cell-Kill Strategies
• Optimal and suboptimal protocols for a mathematical model for tumor anti-angiogenesis in combination with chemotherapy
• Optimal control analysis in the chemotherapy of IgG multiple myeloma
• Optimal controls for a model with pharmacokinetics maximizing bone marrow in cancer chemo\-therapy
• Role of optimal control theory in cancer chemotherapy
• Some optimal control problems in cancer chemotherapy with a toxicity limit
• The influence of PK/PD on the structure of optimal controls in cancer chemotherapy models

Cited in

(7)

• Stochastic modelling of slow-progressing tumors: analysis and applications to the cell interplay and control of low grade gliomas
• Optimizing the delivery of combination therapy for tumors: A mathematical model
• Optimal control problems for the Gompertz model under the Norton-Simon hypothesis in chemotherapy
• Dynamics and optimal control of chemotherapy for low grade gliomas: insights from a mathematical model
• The influence of PK/PD on the structure of optimal controls in cancer chemotherapy models
• Controllability problems for differential Gompertzian dynamic equations
• Optimal control problems for differential equations applied to tumor growth: state of the art

Describes a project that uses

Uses Software

• GPOPS

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