Analysis and rejection sampling of Wright-Fisher diffusion bridges

DOI10.1016/J.TPB.2013.08.005zbMATH Open1302.92080arXiv1306.3522OpenAlexW3102834209WikidataQ41853260 ScholiaQ41853260MaRDI QIDQ481668FDOQ481668

Authors: Robert Griffiths, Steven Neil Evans, Joshua G. Schraiber 

Publication date: 12 December 2014

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: We investigate the properties of a Wright-Fisher diffusion process started from frequency x at time 0 and conditioned to be at frequency y at time T. Such a process is called a bridge. Bridges arise naturally in the analysis of selection acting on standing variation and in the inference of selection from allele frequency time series. We establish a number of results about the distribution of neutral Wright-Fisher bridges and develop a novel rejection sampling scheme for bridges under selection that we use to study their behavior.

Full work available at URL: https://arxiv.org/abs/1306.3522

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zbMATH Keywords

diffusionrejection samplingbridgeWright-Fisher

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Genetics and epigenetics (92D10)

Cites Work

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• An explicit transition density expansion for a multi-allelic Wright-Fisher diffusion with general diploid selection
• On the joint distribution of the maximum and its location for a linear diffusion
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• An approximate sampling formula under genetic hitchhiking

Cited In (8)

• Random walk Green kernels in the neutral Moran model conditioned on survivors at a random time to origin
• Wright-Fisher diffusion bridges
• An informational transition in conditioned Markov chains: applied to genetics and evolution
• Filtering the Wright-Fisher diffusion
• Bayesian inference of selection in the Wright-Fisher diffusion model
• Exact simulation of conditioned Wright-Fisher models
• Barker's algorithm for Bayesian inference with intractable likelihoods
• A path integral formulation of the Wright-Fisher process with genic selection

Uses Software

• mbs
• MSMS

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