Existence and multiplicity of segregated solutions to a cell-growth contact inhibition problem

DOI10.3934/DCDS.2015.35.1479zbMATH Open1317.35108arXiv1311.3454OpenAlexW2318177347WikidataQ59227314 ScholiaQ59227314MaRDI QIDQ484386FDOQ484386

Authors: Gonzalo Galiano, Sergey Shmarev, Julián Velasco 

Publication date: 7 January 2015

Published in: Discrete and Continuous Dynamical Systems (Search for Journal in Brave)

Abstract: We study the the Dirichlet problem for the cross-diffusion system [ partial_tu_i=operatorname{div}left(a_iu_i abla (u_1+u_2) ight)+f_i(u_1,u_2),quad i=1,2,quad a_i=const>0, ] in the cylinder $Q=Omegaimes(0,T]$. The functions $f_i$ are assumed to satisfy the conditions $f_1(0,r)=0$, $f_2(s,0)=0$, $f_1(0,r)$, $f_2(s,0)$ are locally Lipschitz-continuous. It is proved that for suitable initial data $u_0$, $v_0$ the system admits segregated solutions $(u_1,u_2)$ such that $u_{i}in{L}^{infty}(Q)$, $u_1+u_{2}in{C}^0(overlineQ)$, $u_1+u_2>0$ and $u_{1}cdot{u}_2=0$ everywhere in $Q$. We show that the segregated solution is not unique and derive the equation of motion of the surface $Gamma$ which separates the parts of $Q$ where $u_1>0$, or $u_2>0$. The equation of motion of $Gamma$ is a modification of the Darcy law in filtration theory. Results of numerical simulation are presented.

Full work available at URL: https://arxiv.org/abs/1311.3454

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zbMATH Keywords

cross-diffusionnonlinear parabolic systemLagrangian coordinatescontact inhibitionsegregated solutions

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Initial-boundary value problems for second-order parabolic systems (35K51) Nonlinear parabolic equations (35K55) Reaction-diffusion equations (35K57) Degenerate parabolic equations (35K65) Free boundary problems for PDEs (35R35)

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Cited In (6)

• Analysis of cross-diffusion systems for fluid mixtures driven by a pressure gradient
• Analysis of a splitting-differentiation population model leading to cross-diffusion
• Deterministic particle method approximation of a contact inhibition cross-diffusion problem
• Travelling wave solutions of a parabolic-hyperbolic system for contact inhibition of cell-growth
• Incompressible limit of a continuum model of tissue growth for two cell populations
• Incompressible limit of a continuum model of tissue growth with segregation for two cell populations

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