Exact Permutational Tests for Group Sequential Clinical Trials

DOI10.2307/2533442MaRDI QIDQ4844281zbMATH OpenOpenAlexWikidataFDO

Authors Cyrus R. Mehta, Nitin R. Patel, Pralay Senchaudhuri, Anastasios A. Tsiatis

Publication date 22 October 1995

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.2307/2533442

zbMATH Keywords

randomizationalgorithmcategorical dataexact testsstopping boundariesearly stoppingstopping ruleslinear rank statisticsrepeated significance testsinterim monitoringO'Brien-Fleming boundarygroup sequential clinical trialssequential Wilcoxon testerror spending functionsexact boundary generating functionexact joint permutational distributionLan-DeMets procedure

Mathematics Subject Classification ID

Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Probabilistic methods, stochastic differential equations (65C99) Sequential statistical analysis (62L10)

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