Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

DOI10.1016/J.JTBI.2014.09.018zbMATH Open1303.92032OpenAlexW2128558411WikidataQ38952460 ScholiaQ38952460MaRDI QIDQ485684FDOQ485684

Authors: Jessica B. McGillen, Catherine J. Kelly, Alicia Martínez-González, Natasha K. Martin, Eamonn A. Gaffney, Philip K. Maini, Víctor M. Pérez-García 

Publication date: 13 January 2015

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2014.09.018

Recommendations

• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• Analysis of a model for tumor growth and lactate exchanges in a glioma
• A mathematical model of the disruption of glucose homeostasis in cancer patients
• A microscale mathematical model for metabolic symbiosis: investigating the effects of metabolic inhibition on ATP turnover in tumors
• Modelling aspects of tumour metabolism
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Mathematical modelling of the Warburg effect in tumour cords
• Regulation of tumour intracellular pH: a mathematical model examining the interplay between H\(^+\) and lactate
• Cancer metabolism and the dynamics of metastasis

zbMATH Keywords

partial differential equationscancer metabolismmultidimensional sensitivity analysis

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Cites Work

• Random forests
• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Global sensitivity analysis: The primer
• A Compendium of Partial Differential Equation Models
• Computational analysis of the influence of the microenvironment on carcinogenesis

Cited In (7)

• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• Adaptation to stochastic temporal variations in intratumoral blood flow: the Warburg effect as a bet hedging strategy
• Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells
• Unraveling the origin of glucose mediated disparate proliferation dynamics of cancer stem cells
• Analysis of a model for tumor growth and lactate exchanges in a glioma
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Metabolic changes during carcinogenesis: potential impact on invasiveness

Uses Software

• ElemStatLearn

This page was built for publication: Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q485684)