Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy

DOI10.1016/J.JTBI.2014.09.018MaRDI QIDQ485684zbMATH OpenOpenAlexWikidataFDO

Authors Jessica B. McGillen, Catherine J. Kelly, Alicia Martínez-González, Natasha K. Martin, Eamonn A. Gaffney, Philip K. Maini, Víctor M. Pérez-García

Publication date 13 January 2015

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.09.018

zbMATH Keywords

partial differential equationscancer metabolismmultidimensional sensitivity analysis

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

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Cites work

• A Compendium of Partial Differential Equation Models
• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Computational analysis of the influence of the microenvironment on carcinogenesis
• Global sensitivity analysis: The primer
• Random forests

Cited in

(10)

• Unraveling the origin of glucose mediated disparate proliferation dynamics of cancer stem cells
• p53 orchestrates cancer metabolism: unveiling strategies to reverse the Warburg effect
• A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment
• Analysis of a model for tumor growth and lactate exchanges in a glioma
• A microscale mathematical model for metabolic symbiosis: investigating the effects of metabolic inhibition on ATP turnover in tumors
• Adaptation to stochastic temporal variations in intratumoral blood flow: the Warburg effect as a bet hedging strategy
• Tumour glycolysis: the many faces of HIF
• Metabolic changes during carcinogenesis: potential impact on invasiveness
• Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells
• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells

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