Modeling and optimization of populations subject to time-dependent mutation.

DOI10.1073/pnas.92.18.8219zbMath0832.92015OpenAlexW2057871088WikidataQ33958359 ScholiaQ33958359MaRDI QIDQ4856915

Alan S. Perelson, Thomas B. Kepler

Publication date: 5 March 1996

Published in: Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL: https://europepmc.org/articles/pmc41128

zbMATH Keywords

optimal controlMonte Carlo simulationsomatic hypermutationstochastic modelhybrid modelmutation rateaffinity maturationenvironmental conditionsdeterministic threshold modelantibody affinity maturationoptimal mutation schedule

Mathematics Subject Classification ID

Problems related to evolution (92D15)

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