A minimal spatio-temporal model of the NF- B signalling pathway exhibits a range of behaviours

DOI10.1007/S11538-014-0011-2MaRDI QIDQ486608zbMATH OpenOpenAlexWikidataFDO

Authors Alan J. Terry

Publication date 16 January 2015

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-014-0011-2

zbMATH Keywords

cancernegative feedbackgene regulatory networkspatio-temporal modelgenetic oscillatorNF-\(\kappa\)B

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Cell biology (92C37)

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Cites work

• A spatial model of cellular molecular trafficking including active transport along microtubules
• Genetic control models with diffusion and delays
• Interaction of spatial diffusion and delays in models of genetic control by repression
• Mathematical model of NF-\( \kappa\)B regulatory module
• Models of genetic control by repression with time delays and spatial effects
• Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways
• Spatio-temporal modelling of the NF-B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry

Cited in

(10)

• On the effect of circadian oscillations on biochemical cell signaling by NF- B
• A systematic survey of the response of a model NF-\(\kappa\)B signalling pathway to \(\mathrm{TNF}\alpha\) stimulation
• A simple model of NF-\(\kappa\)B dynamics reproduces experimental observations
• \textit{NF}-\(\kappa B\) oscillations and cell-to-cell variability
• Spatio-temporal modelling of the NF-B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• The dynamics of NF-\(\kappa\)B pathway regulated by circadian clock
• Receptor-dependent sensitivity of NF-\(\kappa\)B to low physiological level
• Mathematical model of NF-\( \kappa\)B regulatory module
• NF-\( \kappa\)B spiky oscillations
• Critical roles of I\(\kappa\)B\(\alpha\) and RelA phosphorylation in transitional oscillation in NF-\(\kappa\)B signaling module

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