Exact prior-free probabilistic inference on the heritability coefficient in a linear mixed model
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Publication:489166
DOI10.1214/15-EJS984zbMATH Open1308.62050arXiv1406.3521MaRDI QIDQ489166FDOQ489166
Ryan Martin, Xu Gao, Qianshun Cheng
Publication date: 27 January 2015
Published in: Electronic Journal of Statistics (Search for Journal in Brave)
Abstract: Linear mixed-effect models with two variance components are often used when variability comes from two sources. In genetics applications, variation in observed traits can be attributed to biological and environmental effects, and the heritability coefficient is a fundamental quantity that measures the proportion of total variability due to the biological effect. We propose a new inferential model approach which yields exact prior-free probabilistic inference on the heritability coefficient. In particular we construct exact confidence intervals and demonstrate numerically our method's efficiency compared to that of existing methods.
Full work available at URL: https://arxiv.org/abs/1406.3521
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Cited In (6)
- Confidence distribution inferences in one-way random effects model
- Closed-Form Approximations to the REML Estimator of a Variance Ratio (or Heritability) in a Mixed Linear Model
- Evolutionary State-Space Model and Its Application to Time-Frequency Analysis of Local Field Potentials
- Hereditarity of potential matrices and positive affine prediction of nonnegative risks from mixture models
- False confidence, non-additive beliefs, and valid statistical inference
- On the Estimation of Intra‐Sire Regression Heritability Subject to Linear Constraint
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