Exact prior-free probabilistic inference on the heritability coefficient in a linear mixed model
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Publication:489166
Abstract: Linear mixed-effect models with two variance components are often used when variability comes from two sources. In genetics applications, variation in observed traits can be attributed to biological and environmental effects, and the heritability coefficient is a fundamental quantity that measures the proportion of total variability due to the biological effect. We propose a new inferential model approach which yields exact prior-free probabilistic inference on the heritability coefficient. In particular we construct exact confidence intervals and demonstrate numerically our method's efficiency compared to that of existing methods.
Recommendations
- Heritability estimation in high dimensional sparse linear mixed models
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- scientific article; zbMATH DE number 69506
- Statistical properties of simple random-effects models for genetic heritability
- Empirical likelihood-based inference for genetic mixture models
- Extended Bayesian model averaging for heritability in twin studies
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Cited in
(7)- False confidence, non-additive beliefs, and valid statistical inference
- Heritability estimation in high dimensional sparse linear mixed models
- Confidence distribution inferences in one-way random effects model
- Hereditarity of potential matrices and positive affine prediction of nonnegative risks from mixture models
- Evolutionary state-space model and its application to time-frequency analysis of local field potentials
- Closed-Form Approximations to the REML Estimator of a Variance Ratio (or Heritability) in a Mixed Linear Model
- On the Estimation of Intra‐Sire Regression Heritability Subject to Linear Constraint
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