Mixed-Mode Oscillations in a Multiple Time Scale Phantom Bursting System

DOI10.1137/110860136MaRDI QIDQ4904550zbMATH OpenOpenAlexFDO

Authors M. Krupa, Alexandre Vidal, Mathieu Desroches, Frédérique Clément

Publication date 30 January 2013

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1202.2705

zbMATH Keywords

blow-upfolded nodeGnRH secretionlimit cyclesmixed-mode oscillationsmultiple time scalessecondary canardssectors of rotationsingular perturbationslow-fast systems

Mathematics Subject Classification ID

Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Bifurcation theory for ordinary differential equations (34C23) Relaxation oscillations for ordinary differential equations (34C26) Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations of ordinary differential equations (34D15) Multiple scale methods for ordinary differential equations (34E13) Singular perturbations for ordinary differential equations (34E15) Canard solutions to ordinary differential equations (34E17) Systems with slow and fast motions for nonlinear problems in mechanics (70K70) General biology and biomathematics (92B05)

Abstract: In this work we study mixed mode oscillations in a model of secretion of GnRH (Gonadotropin Releasing Hormone). The model is a phantom burster consisting of two feedforward coupled FitzHugh-Nagumo systems, with three time scales. The forcing system (Regulator) evolves on the slowest scale and acts by moving the slow nullcline of the forced system (Secretor). There are three modes of dynamics: pulsatility (transient relaxation oscillation), surge (quasi steady state) and small oscillations related to the passage of the slow nullcline through a fold point of the fast nullcline. We derive a variety of reductions, taking advantage of the mentioned features of the system. We obtain two results; one on the local dynamics near the fold in the parameter regime corresponding to the presence of small oscillations and the other on the global dynamics, more specifically on the existence of an attracting limit cycle. Our local result is a rigorous characterization of small canards and sectors of rotation in the case of folded node with an additional time scale, a feature allowing for a clear geometric argument. The global result gives the existence of an attracting unique limit cycle, which, in some parameter regimes, remains attracting and unique even during passages through a canard explosion.

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Cited in

(26)

• Mixed-mode oscillations in a piecewise linear system with multiple time scale coupling
• Canard solutions in neural mass models: consequences on critical regimes
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• Multiscale geometry of the Olsen model and non-classical relaxation oscillations
• Mixed-mode bursting oscillations: dynamics created by a slow passage through spike-adding canard explosion in a square-wave burster
• Canard-mediated (de)synchronization in coupled phantom bursters
• Symmetric fold/super-Hopf bursting, chaos and mixed-mode oscillations in Pernarowski model of pancreatic beta-cells
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• Understanding and distinguishing three-time-scale oscillations: case study in a coupled Morris-Lecar system
• Two novel bursting patterns in the Duffing system with multiple-frequency slow parametric excitations
• Coupled multiple timescale dynamics in populations of endocrine neurons: pulsatile and surge patterns of GnRH secretion
• Experimental and numerical observation of successive mixed-mode oscillation-incrementing bifurcations in an extended Bonhoeffer-van der Pol oscillator
• Spike-adding in a canonical three-time-scale model: superslow explosion and folded-saddle canards
• A multiple time scale coupling of piecewise linear oscillators. Application to a neuroendocrine system
• Analysis of interacting local oscillation mechanisms in three-timescale systems
• Fenichel theory for multiple time scale singular perturbation problems
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• Nonlinear complexification of periodic orbits in the generalized Landau scenario
• Models in neuroendocrinology
• Synchrony and canards in two coupled FitzHugh-Nagumo equations
• Complex bifurcation structures and bursting oscillations of an extended Duffing-van der Pol oscillator
• Geometric singular perturbation analysis of a three-timescale coupled reduced Hodgkin-Huxley system
• Saddle slow manifolds and canard orbits in \(\mathbb{R}^{4}\) and application to the full Hodgkin-Huxley model
• Title not available (Why is no real title available?)

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