Mixed-Mode Oscillations in a Multiple Time Scale Phantom Bursting System

DOI10.1137/110860136MaRDI QIDQ4904550zbMATH OpenOpenAlexFDO

Authors M. Krupa, Alexandre Vidal, Mathieu Desroches, Frédérique Clément

Publication date 30 January 2013

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1202.2705

zbMATH Keywords

multiple time scalesblow-upsingular perturbationlimit cyclesslow-fast systemsmixed-mode oscillationsfolded nodesecondary canardsGnRH secretionsectors of rotation

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Nonlinear oscillations and coupled oscillators for ordinary differential equations (34C15) Bifurcation theory for ordinary differential equations (34C23) Singular perturbations for ordinary differential equations (34E15) General biology and biomathematics (92B05) Relaxation oscillations for ordinary differential equations (34C26) Multiple scale methods for ordinary differential equations (34E13) Canard solutions to ordinary differential equations (34E17) Systems with slow and fast motions for nonlinear problems in mechanics (70K70) Singular perturbations of ordinary differential equations (34D15)

Abstract: In this work we study mixed mode oscillations in a model of secretion of GnRH (Gonadotropin Releasing Hormone). The model is a phantom burster consisting of two feedforward coupled FitzHugh-Nagumo systems, with three time scales. The forcing system (Regulator) evolves on the slowest scale and acts by moving the slow nullcline of the forced system (Secretor). There are three modes of dynamics: pulsatility (transient relaxation oscillation), surge (quasi steady state) and small oscillations related to the passage of the slow nullcline through a fold point of the fast nullcline. We derive a variety of reductions, taking advantage of the mentioned features of the system. We obtain two results; one on the local dynamics near the fold in the parameter regime corresponding to the presence of small oscillations and the other on the global dynamics, more specifically on the existence of an attracting limit cycle. Our local result is a rigorous characterization of small canards and sectors of rotation in the case of folded node with an additional time scale, a feature allowing for a clear geometric argument. The global result gives the existence of an attracting unique limit cycle, which, in some parameter regimes, remains attracting and unique even during passages through a canard explosion.

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Cited in

(22)

• Mixed-mode oscillations in a three-timescale coupled Morris-Lecar system
• Mixed-mode bursting oscillations: dynamics created by a slow passage through spike-adding canard explosion in a square-wave burster
• Analysis of interacting local oscillation mechanisms in three-timescale systems
• Spike-adding in a canonical three-time-scale model: superslow explosion and folded-saddle canards
• Fenichel theory for multiple time scale singular perturbation problems
• Multiscale geometry of the Olsen model and non-classical relaxation oscillations
• Multiple geometric viewpoints of mixed mode dynamics associated with pseudo-plateau bursting
• Models in neuroendocrinology
• Symmetric coupling of multiple timescale systems with mixed-mode oscillations and synchronization
• A network model of the periodic synchronization process in the dynamics of calcium concentration in GnRH neurons
• Saddle slow manifolds and canard orbits in \(\mathbb{R}^{4}\) and application to the full Hodgkin-Huxley model
• Understanding and distinguishing three-time-scale oscillations: case study in a coupled Morris-Lecar system
• A multiple time scale coupling of piecewise linear oscillators. Application to a neuroendocrine system
• Canard solutions in neural mass models: consequences on critical regimes
• Two novel bursting patterns in the Duffing system with multiple-frequency slow parametric excitations
• Canard-mediated (de)synchronization in coupled phantom bursters
• Experimental and numerical observation of successive mixed-mode oscillation-incrementing bifurcations in an extended Bonhoeffer-van der Pol oscillator
• Symmetric fold/super-Hopf bursting, chaos and mixed-mode oscillations in Pernarowski model of pancreatic beta-cells
• Coupled multiple timescale dynamics in populations of endocrine neurons: pulsatile and surge patterns of GnRH secretion
• Mixed-mode oscillations in a piecewise linear system with multiple time scale coupling
• Nonlinear complexification of periodic orbits in the generalized Landau scenario
• Complex oscillatory dynamics in a three-timescale El Niño southern oscillation model

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